SavedAdd your journal

Journals / Turkish Journal of Hematology / 2010 / Cilt: 27 - Sayı: 3

Demir taşınımı: Enterositten mitokondriye

Iron transport: From enterocyte to mitochondria

Namık ÖZBEK
Pages
137–146
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review highlights the recent advances in the mechanisms involving transport and delivery of iron to tissues, cellular and mitochondrial iron metabolism, iron-related molecules, and mitochondrial disorders.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Transport of iron to tissues is of vital importance.
📊
Key Findings & Data:Remarkable advances have been made concerning the mechanisms involving iron metabolism after its absorption.
💡
Conclusion & Impact:This review highlights the recent advances in the mechanisms involving transport and delivery of iron to tissues, cellular and mitochondrial iron metabolism, iron-related molecules, and mitochondrial disorders.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Transport of iron to tissues is of vital importance. Remarkable advances have been made concerning the mechanisms involving iron metabolism after its absorption. Studies assessing cellular and mitochondrial iron metabolism have resulted in interesting findings. This review highlights the recent advances in the mechanisms involving transport and delivery of iron to tissues, cellular and mitochondrial iron metabolism, iron-related molecules, and mitochondrial disorders.

Özet

Demirin dokulara taşınması yaşamsal önem taşır. Demirin emiliminden sonraki metabolizmasıyla ilgili büyük ilerlemeler kaydedilmiştir. Selüler ve mitokondriyal demir metabolizmasıyla ilgili araştırmalar ilginç sonuçlar vermektedir. Bu derleme demirin dokulara taşınması, verilmesi, hücresel ve mitokond- riyal demir metabolizması, demirle ilişkili moleküller ve mitokondriyal hastalıklarla ilgili yeni gelişmeleri vurgulamaktadır.

🔖

Cite This Article

ÖZBEK, N. (2010). Demir taşınımı: Enterositten mitokondriye. Turkish Journal of Hematology, Cilt: 27 - Sayı: 3, 137–146. https://ajindex.com/articles/412934

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Mackenzie B, Garrick MD. Iron Imports. II. Iron uptake at the apical membrane in the intestine. Am J Physiol Gastrointest Liver Physiol 2005;289:G981-6
  2. Ma Y, Yeh M, Yeh KY, Glass J. Iron Imports. V. Transport of iron through the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol 2006;290:G417-22
  3. West AR, Oates PS. Mechanisms of heme iron absorption: current questions and controversies. World J Gastroenterol 2008;14:4101-10
  4. Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, Gitschier J, Anderson GJ. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nature Genet 1999;21:195-9
  5. Anderson GJ, Murphy TL, Cowley L, Evans BA, Halliday JW, McLaren GD. Mapping the gene for sex-linked anemia: an inherited defect of intestinal iron absorption in the mouse. Genomics 1998;48:34-9
  6. De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J. The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab 2008;8:146-56
  7. De Domenico I, Lo E, Ward DM, Kaplan J. Hepcidininduced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proc Natl Acad Sci U S A 2009;106:3800-5
  8. Yang F, Lum JB, McGill JR, Moore CM, Naylor SL, van Bragt PH, Baldwin WD, Bowman BH. Human transferrin: cDNA characterization and chromosomal localization. Proc Natl Acad Sci U S A 1984;81:2752-6
  9. Hirose M. The structural mechanism for iron uptake and release by transferrins. Biosci Biotechnol Biochem 2000;64:1328-1336
  10. Harris WR. Estimation of the ferrous-transferrin binding constants based on thermodynamic studies of nickel(II)-transferrin. J Inorg Biochem 1986;27:41-52
  11. Baker HM, Anderson BF, Baker EN. Dealing with iron: common structural principles in proteins that transport iron and heme. Proc Natl Acad Sci U S A 2003;100:3579-83
  12. Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet 1999;21:396-9
  13. Casey JL, Di Jeso B, Rao K, Klausner RD, Harford JB. Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor. Proc Natl Acad Sci U S A 1988;85:1787-91
  14. Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, Gombart AF, Koeffler HP. Molecular cloning of transferrin receptor 2. A new member of the transferin receptorlike family. J Biol Chem 1999;274:20826-