Journals / Turkish Journal of Hematology / 2012 / Cilt: 29 - Sayı: 2

Segmental hemanjiyomun propranolol ile başarılı tedavisi: Bir olgu sunumu

Successful treatment with propranolol in a patient with a segmental hemangioma: A case report

Pages
170–173
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The only problem to occur was disease recurrence following the withdrawal of propranolol at age 13 months, which was not within the age of spontaneous regression (generally considered as >18 months).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The treatment of hemangiomas in infancy may be associated with significant morbidity.
📊
Key Findings & Data:Propranolol was tolerated well and no side effects were observed during the treatment.
💡
Conclusion & Impact:The only problem to occur was disease recurrence following the withdrawal of propranolol at age 13 months, which was not within the age of spontaneous regression (generally considered as >18 months).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The treatment of hemangiomas in infancy may be associated with significant morbidity. In addition to morbidity, an objective response cannot be obtained because of the absence of targeted therapeutic options. Herein, we present an infant with a segmental hemangioma and marked glucocorticoid toxicity due to prior steroid therapy that was successfully treated with propranolol. Propranolol was tolerated well and no side effects were observed during the treatment. The only problem to occur was disease recurrence following the withdrawal of propranolol at age 13 months, which was not within the age of spontaneous regression (generally considered as >18 months).

Özet

Süt çocukluğu döneminde hemanjiyomların tedavisinde önemli yan etkilerle karşılaşılabilmektedir. Hedefe yönelik tedavi seçeneklerinin olmayışı nedeniyle de karşılaşılan morbiditenin yanısıra objektif cevap elde edilmesinde de güçlük çekilmektedir. Bu yazıda segmental hemanjiyomu olan ve steroid tedavisine ikincil ağır glukokortikoid toksisitesi gelişmiş bir süt çocuğunda propranolol tedavisi ile elde edilen başarılı sonuçlar sunulmuştur. Tedavi süresince propranolol iyi tolere edilmiş ve herhangi bir yan etki görülmemiştir. Hasta 13 aylık iken propranolol tedavisinin kesilmesiyle hemanjiyomda tekrarlama görülmüş ve propranolol tekrar başlanmak zorunda kalınmıştır. Hemanjiyomlarda spontan regresyon yaşının 18 aylıktan sonra olduğu düşünülmektedir.

🔖

Cite This Article

KÜPELİ, S., ÇİMEN, D., YAĞCI, B. K. (2012). Segmental hemanjiyomun propranolol ile başarılı tedavisi: Bir olgu sunumu. Turkish Journal of Hematology, Cilt: 29 - Sayı: 2, 170–173. https://ajindex.com/articles/412874

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taïeb A: Propranolol for severe hemangiomas of infancy. N Engl J Med 2008
  2. 2651 2. Nguyen J, Fay A: Pharmacologic therapy for periocular infantile hemangiomas: A review of the literature. Seminars in Opthalmology 2009
  3. 184 3. Jephson CG, Manunza F, Syed S, Mills NA, Harper J, Hartley BE: Successful treatment of isolated subglottic haemangioma with propranolol alone. Int J Pediatr Otorhinolaryngol 2009
  4. 1823 4. Mousa W, Kues K, Haas E, Lauerer P, Pavlakovic H, Schön MP, Zutt M: Successful treatment of a large hemangioma with propranolol. J Dtsch Dermatol Ges 2009
  5. 186 5. Lawley LP, Siegfried E, Todd JL: Propranolol treatment for hemangioma of infancy: Risks and recommendations. Pediatr Dermatol 2009
  6. 614 6. Denoyelle F, Leboulanger N, Enjolras O, Harris R, Roger G, Garabedian EN: Role of Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma. Int J Pediatr Otorhinolaryngol 2009
  7. 1172 7. Pérez RS, Mora PC, Rodríguez JD, Sánchez FR, de Torres Jde L: Treatment of infantile hemangioma with propranolol. Anales de Pediatria (Barc) 2010
  8. 154 8. Theletsane T, Redfern A, Raynham O, Harris T, Prose NS, Khumalo NP: Life-threatening infantile haemangioma: A dramatic response to propranolol. J Eur Acad Dermatol Venereol 2009
  9. 1469 9. Ezekowitz RAB, Mulliken JB, Folkman J: Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med 1992
  10. 1463 10. Perez Payarols J, Pardo Masferrer J, Gomez Bellvert C: Treatment of life-threatening infantile hemangiomas with vincristine. N Engl J Med 1995
  11. 69 11. Hurvitz SA, Hurvitz CH, Sloninsky L, Sanford MC: Successful treatment with cyclophosphamide of life- threatening diffuse hemangiomatosis involving the liver. J Pediatr Hematol Oncol 2000
  12. 532 12. D’Angelo G, Lee H, Weiner RI: cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation. J Cell Biochem 1997
  13. 366 13. Sommers Smith SK, Smith DM: Beta blockade induces apoptosis in cultured capillary endothelial cells. In Vitro Cell Dev Biol Anim 2002
  14. 304 14. Siegfried EC, Keenan WJ, Al-Jureidini S: More on propranolol for hemangiomas of infancy. N Engl J Med 2008
  15. 2846 15. Pavlakovic H, Kietz S, Lauerer P, Zutt M, Lakomek M: Hy