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Journals / Turkish Journal of Hematology / 2015 / Cilt: 32 - Sayı: 1

Nöroblastomu Taklit Eden t(1;22) Pozitif Akut Megakaryoblastik Lösemili Bir Süt Çocuğu

Acute Megakaryoblastic Leukemia with t(1;22) Mimicking Neuroblastoma in an Infant

Müge GÖKÇE
ŞEVKİYE SELİN AYTAÇ EYÜPOĞLU
ŞULE ÜNAL CANGÜL
İlhan ALTAN
FATMA GÜMRÜK
Mualla ÇETİN
Pages
64–67
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Bone marrow evaluation revealed t(1;22)-positive AMKL that responded well to a regimen containing high-dose cytarabine.

📌 3 Key Takeaways

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Objective & Hypothesis:Acute megakaryoblastic leukemia (AMKL) with t(1;22) (p13;q13) is an extremely rare subtype of acute myeloid leukemia that is almost always described in infants. t(1;22) (p13;q13)-positive AMKL with extramedullary infiltration has been previously reported only once in the literature.
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Key Findings & Data:Herein, we report a 3-month-old infant presenting with a pelvic mass and pancytopenia suggesting neuroblastoma.
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Conclusion & Impact:Bone marrow evaluation revealed t(1;22)-positive AMKL that responded well to a regimen containing high-dose cytarabine.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Acute megakaryoblastic leukemia (AMKL) with t(1;22) (p13;q13) is an extremely rare subtype of acute myeloid leukemia that is almost always described in infants. t(1;22) (p13;q13)-positive AMKL with extramedullary infiltration has been previously reported only once in the literature. Herein, we report a 3-month-old infant presenting with a pelvic mass and pancytopenia suggesting neuroblastoma. Bone marrow evaluation revealed t(1;22)-positive AMKL that responded well to a regimen containing high-dose cytarabine.

Özet

Özet: t(1;22) (p13;q13) pozitif akut megakaryoblastik lösemi (AMKL) olgularının neredeyse hepsi sadece süt çocukluğu döneminde bildirilmiş olup, akut miyeloid löseminin son derece nadir bir alt tipidir. Bu olgu sunumunda, pelvik kitle ve pansitopeni ile başvuran ve tanı anında nöroblastomu taklit eden üç aylık bebek sunulmaktadır. Hastanın kemik iliği incelemesi ile t(1;22) pozitif AMKL tanısı konulmuş ve yüksek doz sitarabin içeren tedavi rejimine hasta iyi cevap vermiştir.

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Cite This Article

GÖKÇE, M., EYÜPOĞLU, Ş. S. A., CANGÜL, Ş. Ü., ALTAN, İ., GÜMRÜK, F., ÇETİN, M. (2015). Nöroblastomu Taklit Eden t(1;22) Pozitif Akut Megakaryoblastik Lösemili Bir Süt Çocuğu. Turkish Journal of Hematology, Cilt: 32 - Sayı: 1, 64–67. https://ajindex.com/articles/412805

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References (10)

  1. Tallman MS, Neuberg D, Bennett JM, Francois CJ, Paietta E, Wiernik PH, Dewald G, Cassileth PA, Oken MM, Rowe JM. Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience. Blood 2000;96:2405-2411
  2. Martinez-Climent JA. Molecular cytogenetics of childhood hematological malignancies. Leukemia 1997;11:1999-2021
  3. Hicsonmez G, Cetin M, Tuncer AM, Yenicesu I, Aslan D, Ozyürek E, Unal S. Children with acute myeloblastic leukemia presenting with extramedullary infiltration: the effects of high-dose steroid treatment. Leuk Res 2004;28:25-34
  4. Wechsler J, Greene M, McDevitt MA, Anastasi J, Karp JE, Le Beau MM, Crispino JD. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet 2002;32:148-152
  5. Baruchel A, Daniel MT, Schaison G, Berger R. Nonrandom t(1;22) (p12-p13;q13) in acute megakaryocytic malignant proliferation. Cancer Genet Cytogenet 1991;54:239-243
  6. Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci U S A 2001;98:5776-5779
  7. Creutzig U, Zimmermann M, Bourquin JP, Dworzak MN, Fleischhack G, Graf N, Klingebiel T, Kremens B, Lehrnbecher T, von Neuhoff C, Ritter J, Sander A, Schrauder A, von Stackelberg A, Stary J, Reinhardt D. Randomized trial comparing liposomal daunorubicin with idarubicin in induction for pediatric acute myeloid leukemia: results from Study AML-BFM 2004. Blood 2013;122:37-43
  8. Zeller B, Gustafsson G, Forestier E, Abrahamsson J, Clausen N, Heldrup J, Hovi L, Jonmundsson G, Lie SO, Glomstein A, Hasle H. Nordic Society of Paediatric Haematology and Oncology (NOPHO). Acute leukemia in children with Down syndrome: a population-based Nordic study. Br J Haematol 2005;128:797-804
  9. Rao A, Hills RK, Stiller C, Gibson BE, de Graaf SS, Hann IM, O’Marcaigh A, Wheatley K, Webb DK. Treatment for myeloid leukemia of Down syndrome: population-based experience in the UK and results from the Medical Research Council AML 10 and AML 12 trials. Br J Haematol 2006;132:576-583
  10. Hama A, Yagasaki H, Takahashi Y, Nishio N, Muramatsu H, Yoshida N, Tanaka M, Hidaka H, Watanabe N, Yoshimi A, Matsumoto K, Kudo K, Kato K, Horibe K, Kojima S. Acute megakaryoblastic leukemia (AMKL) in children: a comparison of AMKL with and without Down syndrome. Br J Haematol 2008