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Journals / Turkish Journal of Hematology / 2015 / Cilt: 32 - Sayı: 1

Akut Miyeloid Lösemide Tek Bir Sitogenetik Anormallik Olarak Kromozom 6 Trizomisi

Trisomy Chromosome 6 as a Sole Cytogenetic Abnormality in Acute Myeloid Leukemia

Monika GUPTA
Nita RADHAKRİSHNAN
Manoranjan MAHAPATRA
Renu SAXENA
Pages
77–79
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

More studies are required to ascertain the role of trisomy 6 in the development of leukemia as well as in prognosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Identification of cytogenetic abnormalities plays an important role in the diagnosis and prognosis of leukemias.
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Key Findings & Data:Isolated trisomy 6 is a rare abnormality, the prognostic significance of which is not well established.
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Conclusion & Impact:More studies are required to ascertain the role of trisomy 6 in the development of leukemia as well as in prognosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Identification of cytogenetic abnormalities plays an important role in the diagnosis and prognosis of leukemias. Isolated trisomy 6 is a rare abnormality, the prognostic significance of which is not well established. We report one case of acute myeloid leukemia (AML-M5 variant) with trisomy 6 as the sole cytogenetic abnormality. Previously, trisomy 6 has been reported in aplastic anemia, myelodysplastic syndrome, and AML, usually associated with hypocellular marrow. However, our patient had a very short history and hypercellular marrow infiltrated with blasts. We report this case due to the rarity of the condition. More studies are required to ascertain the role of trisomy 6 in the development of leukemia as well as in prognosis.

Özet

Özet: Sitogenetik anormalliklerin tanımlanması lösemilerin tanı ve prognozunda önemli bir rol oynar. İzole trizomi 6, prognostik önemi iyi belirlenmemiş olan nadir bir anormalliktir. Tek sitogenetik anormallik olarak trizomi 6ya sahip bir akut miyeloid lösemi (AML-M5 varyantı) olgusunu sunuyoruz. Trizomi 6 daha önce aplastik anemi, miyelodisplastik sendrom ve genellikle hiposelüler ilik ile ilişkilendirilmiş AMLde bildirilmiştir. Ancak hastamızın çok kısa bir geçmişi ve blastlar ile infiltre hiperselüler bir iliği vardı. Bu durumun nadirliği nedeni ile bu olguyu rapor ediyoruz. Hem lösemi gelişiminde trizomi 6nın rolünü tespit etmek, hem de prognoz için daha fazla çalışma gereklidir. Anahtar Sözcükler:

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Cite This Article

GUPTA, M., RADHAKRİSHNAN, N., MAHAPATRA, M., SAXENA, R. (2015). Akut Miyeloid Lösemide Tek Bir Sitogenetik Anormallik Olarak Kromozom 6 Trizomisi. Turkish Journal of Hematology, Cilt: 32 - Sayı: 1, 77–79. https://ajindex.com/articles/412797

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