Bortezomib-associated severe orthostatic hypotension and hyponatremia

References (1)

1. Orlowski RZ, Stinchcombe TE, Mitchell BS, Shea TC, Baldwin AS, Stahl S, Adams J, Esseltine DL, Elliott PJ, Pien CS, Guerciolini R, Anderson JK, Depcik-Smith ND, Bhagat R, Lehman MJ, Novick SC, O’Connor OA, Soignet SL. Phase I trial of the proteasome inhibitor PS–341 in patients with refractory hematologic malignancies. J Clin Oncol 2002; 20 (22): 4420-4427 2. O’Connor OA, Wright J, Moskowitz C, Muzzy J, MacGregor- Cortelli B, Stubblefield M, Straus D, Portlock C, Hamlin P, Choi E, Dumetrescu O, Esseltine D, Trehu E, Adams J, Schenkein D, Zelenetz AD. Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin’s lymphoma and mantle cell lymphoma. J Clin Oncol 2005; 23 (4): 676-684 3. Brodmann S, Gyr Klaas E, Cathomas R, Girardi V, von Moos R. Severe hyponatremia in a patient with mantle cell lymphoma treated with bortezomib: A case report and review of the literature. Onkologie 2007; 30 (12): 651-654 4. Rajkumar SV, Richardson PG, Hideshima T, Anderson KC. Proteasome inhibition as a novel therapeutic target in human cancer. J Clin Oncol 2005; 23 (3): 630-639