Süt çocuklarında edinsel methemoglobinemi

Objective & Hypothesis:Objective: This study aimed to determine the etiologic factors of acquired methemoglobinemia in infants younger than three months in our region.

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Key Findings & Data:Material and Methods: This study was carried out retrospectively in infants with methemoglobinemia admitted to Karadeniz Technical University, Pediatric Clinic, during the period 2000-2009.

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Conclusion & Impact:It should not be forgotten that sepsis caused by S. aureus may cause methemoglobinemia in infants.

🔬Design:Research Article

📍Scope:2000-2009 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: This study aimed to determine the etiologic factors of acquired methemoglobinemia in infants younger than three months in our region. Material and Methods: This study was carried out retrospectively in infants with methemoglobinemia admitted to Karadeniz Technical University, Pediatric Clinic, during the period 2000-2009. Infants with methemoglobinemia were identified according to the medical records or ICD-10 code. Results: Nine infants with acquired methemoglobinemia (8 male, 1 female) were included in the study. Seven cases were associated with the use of prilocaine for circumcision, one case with the use of prilocaine- lidocaine for local pain therapy, and one case with neonatal sepsis caused by Staphylococcus aureus. Conclusion: Prilocaine should not be used in infants less than three months of age because of the risk of methemoglobinemia. Ascorbic acid is an effective therapy if methylene blue is not obtained. It should not be forgotten that sepsis caused by S. aureus may cause methemoglobinemia in infants.

Özet

Amaç: Bölgemizde üç aydan küçük bebeklerde meydana gelen akkiz methemoglobinemilerin etiyolo- jisini araştırmak. Yöntem ve Gereçler: Bu çalışma, 2000-2009 yılları arasında pediatri kliniğine başvuran ve ICD-10 koduna veya hasta kayıt defterine göre akkiz methemoglobinemi tanısı alan hastaların kayıtlarının retrospektif incelenmesi ile gerçekleştirildi. Bulgular: Sekizi erkek olmak üzere, dokuz akkiz methemoglobinemili infant çalışmaya alındı. Yedi vaka; sünnet için prilokain kullanımı ile ilişkili iken, bir vaka; lokal anestezi için kullanılan prilokain– lidokain ile ve diğer vaka ise; Staphylococcus aureus sepsisi ile ilişkili idi. Sonuç: Üç aydan küçük infantlarda prilokain methemoglobinemi riski nedeniyle kullanılmamalıdır ve metilen mavisi elde edilemediği durumlarda vitamin C effektif bir tedavi şeklidir. Staphylococcus aureus’a bağlı sepsisin infantlarda methemoglobinemiye neden olabileceği unutulmamalıdır.

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Cite This Article

MUTLU, M., ERDURAN, E., ASLAN, Y. (2011). Süt çocuklarında edinsel methemoglobinemi. Turkish Journal of Hematology, Cilt: 28 - Sayı: 2, 131–134. https://ajindex.com/articles/412689

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References (6)

Ash-Bernal R, Wise R, Wright SM. Acquired methemo- globinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine (Baltimore) 2004;83:265-73. [CrossRef] moglobinemia: a rare cause of cyanosis in the newborn- a case report. Pediatrics 2003;112:e158-61. Ohashi K, Yukioka H, Hayashi M, Asada A. Elevated met- hemoglobin in patients with sepsis. Acta Anaesthesiol Scand 1998;42:713-6. [CrossRef] May RB. An infant with sepsis and methemoglobinemia. J Emerg Med 1985;3:261-4.
Mansouri A, Lurie AA. Concise review: methemoglobin- emia. Am J Hematol 1993;42:7-12. [CrossRef] Greer FR, Shannon M. American Academy of Pediatrics Committee on Nutrition; American Academy of Pediatrics Committee on Environmental Health. Infant methemo- globinemia: the role of dietary nitrate in food and water. Pediatrics 2005;116:784-6. [CrossRef] Vasters FG, Eberhart LH, Koch T, Kranke P Wulf H, Morin AM. Risk factors for prilocaine-induced methaemoglobi- naemia following peripheral regional anaesthesia. Eur J Anaesthesiol 2006;23:760-5. [CrossRef] Panin G, Pernechele M, Giurioli R, Secchieri S, Milanesi O, Pellegrino PA, Chiandetti L. Cytochrome b5 reductase activity in erythrocytes and leukocytes as related to sex and age. Clin Chem 1984;30:701-3. Guay J. Methemoglobinemia related to local anesthet- ics: a summary of 242 episodes Anesth Analg 2009;108:837-45. [CrossRef] Book A, Fehlandt C, Krija M, Radke M, Pappert D. Methemoglobin intoxication by prilocaine in EMLA. Accidental intoxication of an infant with scald injuries. Anaesthesist 2009;58:370-4. [CrossRef] Ochoa JB, Udekwu AO, Billiar TR, Curran RD, Cerra FB, Simmons RL, Peitzman AB. Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg 1991;214:621-6. [CrossRef] Lorente JA, Delgado MA, Landín L. Septic shock and nitric oxide. Enferm Infecc Microbiol Clin 1997;3:14-9.
Wennmalm A, Benthin G, Petersson AS. Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemo- globin. Br J Pharmacol 1992;106:507-8.
Burke KA, Lascelles J. Nitrate reductase activity in heme- deficient mutants of Staphylococcus aureus. J Bacteriol 1976;126:225-31.
Mutlu M, Erduran E, Aksoy A, Aslan Y. Methemoglobinemia associated with Staphylococcus aureus sepsis in a new- born. JNPM 2010;3:63-5.
Hoffman R, Benz E, Shattil S, Furie B, Cohen H. Hematology Basic Principles and Practice. New York: Churchill Livingstone, 2005;650-7. Gibson QH. The reduction of methemoglo