AI Summary & Key Takeaways
AI InsightConclusion: The study s findings show that the DRB1*15 allele might have contributed to the occurrence of inhibitor in the Thai hemophilia A patients; however, additional research using larger samples and high-resolution DRB1 typing is warranted.
📌 3 Key Takeaways
Abstract
Objective: This study aimed to investigate the association between HLA class II alleles and the occurrence of FVIII inhibitor in Thai hemophilia A patients. Material and Methods: The distribution of HLA-DRB1 alleles and DQB1 alleles in 57 Thai hemophilia A patients and 36 blood donors as controls was determined using the PCR sequence-specific primer (PCR-SSP) method, and the association between the occurrence of factor VIII (FVIII) inhibitor and the presence of certain HLA class II alleles was investigated. Results: The frequency of HLA-DRB1*15 was higher in the hemophilia A patients with and without FVIII inhibitor, whereas that of DRB1*14, DRB1*07, and DQB1*02 was lower in the hemophilia A patients with FVIII inhibitor, as compared to controls. Interestingly, only the frequency of DRB1*15 was significantly higher in the patients with inhibitor than in the controls (P = 0.021). Moreover, the frequency of DRB1*15 in the patients with inhibitor was higher than in those without inhibitor (P = 0.198). Conclusion: The study s findings show that the DRB1*15 allele might have contributed to the occurrence of inhibitor in the Thai hemophilia A patients; however, additional research using larger samples and high-resolution DRB1 typing is warranted.
Özet
Amaç: Bu çalışmada HLA sınıf II allelleri hemofili A ile Taylandlı hastalarda FVIII inhibitörü oluşumu ile ilişkiyi araştırmaktır. Gereç ve Yöntemler: Hemofili 57 Taylandlı hastalarda HLA-DRB1 allelleri ve DQB1 allel dağılımı bir PCR-sıra özel astar (PCR-SSP) yöntemi ve faktör VIII (FVIII) inhibitör oluşumu arasındaki ilişki kullanılarak belirlendi ve bazı HLA klas II allelleri varlığı araştırılmıştır. Bulgular: HLA-DRB1 sıklığı * 15 ve FVIII inhibitörü olmayan iki hemofili hastalarında artmış iken DRB1 olanlar * 14, DRB1 * 07 ve DQB1 * 02 FVIII inhibitörleri ile hemofili hastalarında azalmıştı. İlginçtir, sadece DRB1 * 15 önemli kontrol (P = 0.021) ile karşılaştırıldığında inhibitörleri olan hastalarda artmıştır. Ayrıca, inhibitörü olan hastalarda DRB1 * 15 frekans olmayan inhibitörü (P = 0.198) olan hastalarda daha yüksek olma eğiliminde. Sonuç: Bulgularımız DRB1 * 15 allel Tay hemofili A hastalarında inhibitör oluşumuna katkıda bulunabileceğini göstermiştir. Ancak, daha büyük bir örneklem büyüklüğü ve yüksek çözünürlüklü DRB1 yazarak garantilidir.