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Journals / Turkish Journal of Hematology / 2013 / Cilt: 30 - Sayı: 1

Endotelyal protein C reseptörü ve pediatrik arteriyel inme

Endothelial protein C receptor and pediatric arterial stroke

Nejat AKAR
Afife KARABIYIK
Gülhis DEDA
Pages
37–39
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Further study on sEPCR levels at the onset of pediatric stroke is needed in order to reach a more definitive conclusion.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to investigate the endothelial protein C receptor (EPCR) gene A3 haplotype and plasma soluble EPCR (sEPCR) levels in Turkish pediatric arterial stroke patients.
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Key Findings & Data:Materials and Methods: We analyzed 44 pediatric arterial stroke patients and 75 healthy controls.
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Conclusion & Impact:Conclusion: Further study on sEPCR levels at the onset of pediatric stroke is needed in order to reach a more definitive conclusion.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to investigate the endothelial protein C receptor (EPCR) gene A3 haplotype and plasma soluble EPCR (sEPCR) levels in Turkish pediatric arterial stroke patients. Materials and Methods: We analyzed 44 pediatric arterial stroke patients and 75 healthy controls. Following DNA isolation, genotyping of the A3 haplotype was determined via PCR and RFLP. Additionally, fasting sEPCR levels were determined via ELISA. Results: There wasn’t a significant difference in the sEPCR level between the control and patient groups, although the sEPCR level was higher in the patient group. We didn’t observe a difference in the distribution of the CC and CG/GG genotypes between the control and patient groups. Conclusion: Further study on sEPCR levels at the onset of pediatric stroke is needed in order to reach a more definitive conclusion.

Özet

Amaç: Çalışmanın amacı, Türk populasyonundaki pediatrik arteriyel inme hastalarındaki Endotelyal Protein C Reseptörü (EPCR) geni A3 Haplotipi ve plazma solubl EPCR (sEPCR) seviyesinin araştırılmasıdır. Yöntemler: Bu çalışmayla 44 pediatrik arteriyel inme hastası ve 75 sağlıklı kontrol analiz edildi. DNA izolasyonunu takiben, PCR ve RFLP yöntemleri kullanılarak A3 haplotipi genotiplendirilmesi yapıldı ve ELISA aracılığıyla da sEPCR seviyeleri saptandı. Bulgular: Sağlıklı kontrol ve hasta grubu arasında sEPCR seviyesi açısından istatistiksel olarak anlamlı bir fark bulunmamasına ragmen, pediatrik arteriyel inme hastalarına ait grupta sEPCR seviyesi daha yüksek saptanmıştır. Sonuç: Daha etkili bir sonuca varabilmek için pediatrik inmede plazma EPCR seviyelerinin araştırılacağı çalışmalara ihtiyaç vardır

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Cite This Article

AKAR, N., KARABIYIK, A., DEDA, G. (2013). Endotelyal protein C reseptörü ve pediatrik arteriyel inme. Turkish Journal of Hematology, Cilt: 30 - Sayı: 1, 37–39. https://ajindex.com/articles/412577

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