SavedAdd your journal

Journals / Turkish Journal of Hematology / 2015 / Cilt: 32 - Sayı: 3

Mantle Hücreli Lenfoma Tanısı ile Rituksimab Kullanan Bir Hastada Leuconostoc Menenjiti

Leuconostoc sp. Meningitis in a Patient Treated with Rituximab for Mantle Cell Lymphoma

HRVOJE HOLIK
Bozena COHA
MARIJAN SISKO
Maja TONIC PARADZIK
Pages
271–274
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The patient was treated with meropenem with full recovery

📌 3 Key Takeaways

🎯
Objective & Hypothesis:We present a 64-year-old man who was treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemoimmunotherapy for mantle cell lymphoma and developed purulent meningitis, probably caused by Leuconostoc sp.
📊
Key Findings & Data:The patient had severe hypogammaglobulinemia, which is a possible complication of rituximab therapy.
💡
Conclusion & Impact:The patient was treated with meropenem with full recovery
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

We present a 64-year-old man who was treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemoimmunotherapy for mantle cell lymphoma and developed purulent meningitis, probably caused by Leuconostoc sp. The patient had severe hypogammaglobulinemia, which is a possible complication of rituximab therapy. To our knowledge and after reviewing the available medical literature, this is the first described case of purulent meningitis caused by Leuconostoc sp. in a patient with mantle cell lymphoma that appeared after treatment with the R-CHOP protocol. The diagnosis of purulent meningitis was based on clinical, laboratory and cytological cerebrospinal fluid findings, in addition to blood culture results in which we isolated Leuconostoc sp. The patient was treated with meropenem with full recovery

Özet

Burada mantle hücreli lenfoma tanısı ile R-CHOP (rituksimab, siklofosfamid, doksorubisin, vinkristin, prednizolon) kemoimmünoterapisi ile tedavi edilen ve muhtemelen Leuconostoc cinsi etkene bağlı pürülan menenjit gelişen 64 yaşında bir erkek hastayı sunuyoruz. Hastanın rituksimab tedavisinin olası komplikasyonlarından biri olan ağır hipogammaglobulinemisi bulunmakta olup, bildiğimiz kadarı ile ve mevcut tıbbi literatürün taranması sonrasında, olgumuz R-CHOP protokolü ile tedavi sonrası Leuconostoc cinsi etkene bağlı pürülan menejit gelişen mantle hücreli lenfoma tanılı ilk hastadır. Pürülan menenjit tanısı klinik bulgular, laboratuvar ve beyin-omurilik sıvısının sitolojik bulguları ve Leuconostoc izole ettiğimiz kan kültürünü temel alıyordu. Hasta meropenem tedavisi ile tamamen iyileşti

🔖

Cite This Article

HOLIK, H., COHA, B., SISKO, M., PARADZIK, M. T. (2015). Mantle Hücreli Lenfoma Tanısı ile Rituksimab Kullanan Bir Hastada Leuconostoc Menenjiti. Turkish Journal of Hematology, Cilt: 32 - Sayı: 3, 271–274. https://ajindex.com/articles/412517

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Gea-Banacloche JC. Rituximab-associated infections. Semin Hematol 2010;47:187-198.
  2. Lehman DC, Mahon CR, Suvarna K. Streptococcus, Enterococcus and other catalase-negative gram-positive cocci. In: Mahon CR, Lehman DC, Manuselis G, (eds). Textbook of Diagnostic Microbiology, 3rd ed. St. Louis, Saunders Elsevier, 2007.
  3. Ruoff KL. Leuconostoc, Pediococcus, Stomatococcus and miscellaneous gram-positive cocci that grow aerobically. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH (eds). Manual of Clinical Microbiology, 7th ed. Washington DC, American Society for Microbiology, 1999.
  4. Janow G, Lambert B, Scheiner M, Rosen O, Goldman DL, Soghier L. Leuconostoc septicemia in a preterm neonate on vancomycin therapy: case report and literature review. Am J Perinatol 2009;26:89-91.
  5. Yossuck P, Miller-Canfield P, Moffett K, Graeber J. Leuconostoc spp. sepsis in an extremely low birth weight infant: a case report and review of the literature. W V Med J 2009;105:24-27.
  6. Handwerger S, Horowitz H, Coburn K, Kolokathis A, Wormser GP. Infection due to Leuconostoc species: six cases and review. Rev Infect Dis 1990;12:602-610.
  7. Florescu D, Hill L, Sudan D, Iwen PC. Leuconostoc bacteremia in pediatric patients with short bowel syndrome: case series and review. Pediatr Infect Dis J 2008;27:1013- 1019. Friedland IR, Snipelisky M, Khoosal M. Meningitis in a neonate caused by Leuconostoc sp. J Clin Microbiol 1990;28:2125-2126.
  8. Coovadia YM, Solwa Z, van den Ende J. Meningitis caused by vancomycin-resistant Leuconostoc sp. J Clin Microbiol 1987;25:1784-1785. Starr JA. Leuconostoc species-associated endocarditis. Pharmacotherapy 2007;27:766-770.
  9. Deye G, Lewis J, Patterson J, Jorgensen J. A case of Leuconostoc ventriculitis with resistance to carbapenem antibiotics. Clin Infect Dis 2003;37:869-870.
  10. Aksoy S, Dizdar O, Hayran M, Harputluoğlu H. Infectious complications of rituximab in patients with lymphoma during maintenance therapy: a systematic review and meta- analysis. Leuk Lymphoma 2009;50:357-365.
  11. Azad A, Campbell P. High rates of infection associated with the use of maintenance rituximab monotherapy in non- Hodgkin lymphoma. Intern Med J 2009;39:778-779.
  12. Rafailidis PI, Kakisi OK, Vardakas K, Falagas ME. Infectious complications of monoclonal antibodies used in cancer therapy: a systematic review of the evidence from randomized controlled trials. Cancer 2007;109:2182-2189.
  13. Ganjoo KN, Raman R, Sobel RA, Pinto HA. Opportunistic enteroviral meningoencephalitis: an unusual treatab