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Journals / Turkish Journal of Pediatrics / 2016 / Cilt: 58 - Sayı: 5

The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen

İbrahim İlker ÇETİN
FİLİZ EKİCİ
ABDULLAH KOCABAŞ
Berna Şaylan ÇEVİK
Sancar EMİNOĞLU
Emine AZAK
Ayşe Esin KİBAR
Mehmet Emre ARI
Murat SÜRÜCÜ
Ali ORGUN
Pages
473–479
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, NXN is a safe and effective alternative to ASA in the treatment of ARF in children.

📌 3 Key Takeaways

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Objective & Hypothesis:Çetin İİ, Ekici F, Kocabaş A, Çevik BŞ, Eminoğlu S, Azak E, Kibar AE, Arı ME, Sürücü M, Orgun A.
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Key Findings & Data:The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen.
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Conclusion & Impact:In conclusion, NXN is a safe and effective alternative to ASA in the treatment of ARF in children.
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:Domain Parameters

Özet

Çetin İİ, Ekici F, Kocabaş A, Çevik BŞ, Eminoğlu S, Azak E, Kibar AE, Arı ME, Sürücü M, Orgun A. The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen. Turk J Pediatr 2016; 58: 473-479.The objective was to compare the efficacy and safety of naproxen (NXN) to acetylsalicylic acid (ASA) in the treatment of acute rheumatic fever (ARF). The data of 338 children were retrospectively analyzed. The patients were grouped according to joint and valve involvement and also drug chosen [methyl prednisolone (mPSL), ASA or NXN]. The treatment results and adverse events in each group were compared. The mean age was 10.3 years and the median follow-up was 62 months. Median time for normalization of acute phase reactants was 1 week in patients given steroids and 2 weeks in patients given ASA or NXN. ASA was replaced with NXN in 18 patients (10.2%) due to hepatic toxicity. The rate of rebound, recurrence and the prevalence of rheumatic valve disease were not different in patients given NXN, ASA or mPSL. In conclusion, NXN is a safe and effective alternative to ASA in the treatment of ARF in children.

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Cite This Article

ÇETİN, İ. İ., EKİCİ, F., KOCABAŞ, A., ÇEVİK, B. Ş., EMİNOĞLU, S., AZAK, E., KİBAR, A. E., ARI, M. E., SÜRÜCÜ, M., ORGUN, A. (2016). The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen. Turkish Journal of Pediatrics, Cilt: 58 - Sayı: 5, 473–479. https://ajindex.com/articles/412252

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