AI Summary & Key Takeaways
AI InsightAdditionally, this option seems to be more effective toreduce length of hospital stay.
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Özet
Despite the large variety of inhaled treatment options of acute bronchiolitis,there is no generally agreed treatment regime. This study aimed to determinethe most appropriate treatment option. This was a double-blind randomizedprospective clinical trial and has been performed in emergency department. Themean age of the 378 infants included in the study was 7.63 ± 4.6 months,and 54.8% (207) were boys. Patients were randomized by using the lotterymethod for simple random sample into 5 different treatment options; 3%hypertonic saline, nebulized adrenaline, nebulized adrenaline mixed with 3%hypertonic saline, nebulized salbutamol, and as control group; normal saline(0.9% NaCl). From the first treatment time until discharge time; treatmentdurations, adverse events and readmission rates within the first fifteendays were recorded for each patient. Nebulized adrenaline mixed with 3%hypertonic saline, as compared with other options, were associated with asignificantly higher discharge rate at 4th hours (p<0.001) and shorter lengthof hospital stay (p=0.039). However, there was no significant differencebetween options with regard to adverse events, discharge rates at 24thhours, and readmission rates within the first fifteen days. The superiority ofdischarge rates at 4 hours of nebulized adrenaline mixed with 3% hypertonicsaline, was evaluated as ‘better acute response’ and can be helpful to reducehospitalization needs. Additionally, this option seems to be more effective toreduce length of hospital stay.