Dietary intake of high vitamin C containingfoods was discouraged and adequate hydration advised.Nutritional management is crucial in preventing acute stress events in patientswith G6PD deficiency.
📌 3 Key Takeaways
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Objective & Hypothesis:The objective was to describe the nutritional management of a 4-year-oldchild with glucose-6-phosphate dehydrogenase (G6PD) deficiency.A 4-year-old male child, African descent, born from non-consanguineousparents presented with a clinical history of frequent respiratory infections,usually treated with antibiotics.
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Key Findings & Data:At 30 months of age, G6PD diagnosis wasmade after eating one portion (40 – 60 g) of fava beans, resulting in severehemolytic anemia hospitalization for 5 days.
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Conclusion & Impact:Dietary intake of high vitamin C containingfoods was discouraged and adequate hydration advised.Nutritional management is crucial in preventing acute stress events in patientswith G6PD deficiency.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
The objective was to describe the nutritional management of a 4-year-oldchild with glucose-6-phosphate dehydrogenase (G6PD) deficiency.A 4-year-old male child, African descent, born from non-consanguineousparents presented with a clinical history of frequent respiratory infections,usually treated with antibiotics. At 30 months of age, G6PD diagnosis wasmade after eating one portion (40 – 60 g) of fava beans, resulting in severehemolytic anemia hospitalization for 5 days. Diagnosis was confirmed byG6PD activity measurement. Nutritional counseling was given to avoid dietaryoxidative stressors particularly the exclusion of fava beans and accidentalingestion of other similar beans. Dietary intake of high vitamin C containingfoods was discouraged and adequate hydration advised.Nutritional management is crucial in preventing acute stress events in patientswith G6PD deficiency.
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Cite This Article
PINTO, A., MACDONALD, A., CLETO, E., ALMEIDA, M. F., RAMOS, P. C., ROCHA, J. C. (2017). A case report of a 4-year-old child with glucose-6-phosphate dehydrogenase deficiency: An evidence based approach to nutritional management. Turkish Journal of Pediatrics, Cilt: 59 - Sayı: 2, 189–192. https://ajindex.com/articles/412192
Frank JE. Diagnosis and management of G6PD deficiency. Am Fam Physician 2005; 72: 1277-1282
Odièvre M-H, Danékova N, Mesples B, et al. Unsuspected glucose-6-phosphate dehydrogenase deficiency presenting as symptomatic methemoglobinemia with severe hemolysis after fava bean ingestion in a 6-yearold boy. Int J Hematol 2011; 93: 664-666
Zuccotti GV, Redaelli F, Gualdi V, et al. Hemolytic crisis in a G6PD-deficient infant after ingestion of pumpkin. Ital J Pediatr 2014; 40: 71
Laquale KM. Glucose-6-phosphate dehydrogenase (G6PD) deficiency and exercise. Athlet Ther Today 2009; 14: 26-31
Finaud J, Lac G and Filaire E. Oxidative stress: relationship with exercise and training. Sports Med 2006; 36: 327-358
Nikolaidis MG, Jamurtas AZ, Paschalis V, et al. Exerciseinduced oxidative stress in G6PD-deficient individuals. Med Sci Sports Exerc 2006; 38: 1443-1450
Beutler E. G6PD deficiency. Blood 1994; 84: 3613-3636
Hafez M, Amar ES, Zedan M, et al. Improved erythrocyte survival with combined vitamin E and selenium therapy in children with glucose-6-phosphate dehydrogenase deficiency and mild chronic hemolysis. J Pediatr 1986; 108: 558-561
Tsakiris S, Reclos GJ, Parthimos T, Tsakiris T, Parthimos N, Schulpis KH. α-tocopherol supplementation restores the reduction of erythrocyte glucose-6-phosphate dehydrogenase activity induced by forced training. Pharmacol Res 2006; 54: 373-379
Schulpis KH, Reclos GJ, Parthimos T, Parthimos N, Gavriilidis A, Tsakiris S. L-cysteine supplementation protects the erythrocyte glucose-6-phosphate dehydrogenase activity from reduction induced by forced training. Clin Biochem 2006; 39: 1002-1006
Georgakouli K, Deli CK, Zalavras A, et al. α-lipoic acid supplementation up-regulates antioxidant capacity in adults with G6PD deficiency. Food Chem Toxicol 2013; 61: 69-73.