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Journals / Turkish Journal of Pediatrics / 2018 / Cilt: 60 - Sayı: 4

Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission

Helen Aghdasi BORNAUN
Günsel KUTLUK
Gonca KESKİNDEMİRCİ
Kazım ÖZTARHAN
Reyhan DEDEOĞLU
Nuh YILMAZ
Öykü TOSUN
Pages
407–414
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thisimbalance has a circadian rhythm and it is more obvious during the day.These observations may suggest a previously unrecognized role of chronicinflammation for autonomic modulation in IBD.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Heart Rate Variability (HRV) is one of the reliable and noninvasive parametersto evaluate autonomic control of the cardiovascular system in patients.
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Key Findings & Data:Autonomic cardiovascular function was evaluated bytime and frequency-domain indexes of spontaneous heart rate in 36 IBDchildren patients in remission phase and 36 sex and age matched healthycontrols.
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Conclusion & Impact:Thisimbalance has a circadian rhythm and it is more obvious during the day.These observations may suggest a previously unrecognized role of chronicinflammation for autonomic modulation in IBD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Heart Rate Variability (HRV) is one of the reliable and noninvasive parametersto evaluate autonomic control of the cardiovascular system in patients. Theaim of our study was to assess autonomic function in pediatric patientswith inflammatory bowel disease (IBD) in remission using Power SpectralAnalysis of HRV. Autonomic cardiovascular function was evaluated bytime and frequency-domain indexes of spontaneous heart rate in 36 IBDchildren patients in remission phase and 36 sex and age matched healthycontrols. Twenty children with Ulcerative Colitis (UC) and 16 patients withCrohn’s disease (CD) were diagnosed according to their history, physicaland laboratory examination, endoscopic, histopathological and radiologicalfindings of upper and lower gastrointestinal system. Significant decrease wasobserved at HRV parameters in IBD patients when compared with controlgroup. These differences was found in some of time domain parameters(NNmean, SDNNtotal, SDNNday) and frequency domain parameters (TP,LF,VLF) (p<0.05). Also, there was a significant higher minimum heart rateratio (p<0.04) in patients in comparison to the control group. In the IBDgroup, there was a relative tendency for parasympathetic suppression andsympathetic predominance which reflects an autonomic dysfunction. Thisimbalance has a circadian rhythm and it is more obvious during the day.These observations may suggest a previously unrecognized role of chronicinflammation for autonomic modulation in IBD.

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Cite This Article

BORNAUN, H. A., KUTLUK, G., KESKİNDEMİRCİ, G., ÖZTARHAN, K., DEDEOĞLU, R., YILMAZ, N., TOSUN, Ö. (2018). Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission. Turkish Journal of Pediatrics, Cilt: 60 - Sayı: 4, 407–414. https://ajindex.com/articles/412152

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References (14)

  1. Wehkamp J, Götz M, Herrlinger K, Steurer W, F Stange EF. Inflammatory bowel disease Crohn’s disease and ulcerative colitis. Dtsch Arztebl Int 2016; 113: 72-82
  2. Sharma P, Makharia GK, Ahuja V, Dwivedi SN, Deepak KK. Autonomic dysfunctions in patients with inflammatory bowel disease in clinical remission. Digest Dis Sci 2009; 54: 853-861
  3. Furlan R, Ardizzone S, Palazzolo L, et al. Sympathetic overactivity in active ulcerative colitis: effects of clonidine. Am J Physiol Regul Integr Comp Physiol 2006; 290: R224-R232
  4. Furlan R, Guzzetti S, Crivellaro W, et al. Continuous 24.hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects. Circulation 1990; 81: 537-547
  5. Turner D, Otley AR, Mack D, et al. Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. Gastroenterology 2007; 133: 423-432
  6. Hyams JS, Ferry GD, Mandel FS, et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr 1991; 12: 439-447
  7. Wang M, Yip GW, Wang AY, Zhang Y. Peak Early Diastolic Mitral Annulus Velocity by Tissue Doppler Imaging Adds Independent and Incremental Prognostic Value. JACC 2003; 41: 5
  8. Bornaun HA, Yılmaz N, Kutluk G, et al. Prolonged P-wave and QT dispersion in children with inflammatory bowel disease in remission. Biomed Res Int 2017; 2017: 6960810
  9. Dantas EM, Sant'Anna ML, Andreão RV, et al. Spectral analysis of heart rate variability with the autoregressive method: What model order to choose?. Comput Biol Med 2012; 42: 164-170
  10. Marek M. Committee of the Task Force. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996; 93: 1043-1065
  11. Kucharzik T, Maaser C, Lügering A, et al. Recent understanding of IBD pathogenesis: implications for future therapies. Inflamm Bowel Dis 2006; 12: f1068-f1083
  12. Furlan R, Ardizzone S, Palazzolo L, Rimoldi A. Sympathetic overactivity in active ulcerative colitis: effects of clonidine. Am J Physiol Regul Integr Comp Physiol 2006; 290: 224-232
  13. Bishop AE and Polak JM. The gut and the autonomic nervous system. In: Autonomic Failure: a Textbook of Clinical Disorders of the Autonomic Nervous System, edited by Bannister R and Mathias CJ. Oxford. 1992: 160-177
  14. Tsuji H, L