He had massive hemoptysis followingbronchoscopy and recovered succesfully with treatment.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Goodpasture syndrome is a rare, autoimmune disease associated with thedevelopment of antibodies against a specific antigen both in glomerularbasement membrane and alveolar basement membrane.
📊
Key Findings & Data:Herein we report a 14-yearold boy with isolated lung involvement.
💡
Conclusion & Impact:He had massive hemoptysis followingbronchoscopy and recovered succesfully with treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
Goodpasture syndrome is a rare, autoimmune disease associated with thedevelopment of antibodies against a specific antigen both in glomerularbasement membrane and alveolar basement membrane. It is very rarein childhood and its incidence is not known. Although the mechanismof the disease is the same in lung as in the kidney, sometimes it presentswith involvement of only one organ. Pulmonary involvement may be lifethreatening in patients with massive hemoptysis. Herein we report a 14-yearold boy with isolated lung involvement. He had massive hemoptysis followingbronchoscopy and recovered succesfully with treatment.
🔖
Cite This Article
EYÜBOĞLU, T. Ş., ASLAN, A. T., YILDIRIM, D. G., BUYAN, N., EMEKSİZ, S., KALKAN, G. (2019). What triggered massive hemoptysis in Goodpasture syndrome with isolated pulmonary involvement in a 14-year-old boy?. Turkish Journal of Pediatrics, Cilt: 61 - Sayı: 4, 611–614. https://ajindex.com/articles/412101
Hellmark T, Segelmark M. Diagnosis and classification of Goodpasture's disease (anti- GBM). J Autoimmun 2014; 48-49: 108-112
Huart A, Josse AG, Chauveau D, et al; French Society of Hemapheresis. Outcomes of patients wiyh Goodpasture syndrome: A nationwide cohort-based study from the French Society of Hemapheresis. J Autoimmun 2016; 73: 24-29
Greco A, Rizzo MI, De Virgilio A, et al. Goodpasture's syndrome: A clinical update. Autoimmun Rev 2015; 14: 246-253
Peto P, Salama AD. Update on antiglomerular basement membrane disease. Curr Opin Rheumatol 2011; 23: 32-37
Dammacco F, Battaglia S, Gesualdo L, Racanelli V. Goodpasture's disease: A report of ten cases and a review of the literature. Autoimmun Rev 2013; 12: 1101-1108
Segelmark M, Hellmark T, Wieslander J. The prognostic significance in Goodpasture’s disease of specificity, titre and affinity of anti-glomerular basement- membrane antibodies. Nephron Clin Pract 2003; 94: c59-c68
Westman KW, Ericsson UB, Hoier-Madsen M, et al. Prevalence of autoantibodies associated with glomerulonephritis, unaffected after extracorporeal shock wave lithotripsy for renal calculi, in a threeyear follow-up. Scand J Urol Nephrol 1997; 31: 463-467
García-Rostan y Pérez GM, García Bragado F, Puras Gil AM. Pulmonary hemorrhage and antiglomerular basement membrane antibody-mediated glomerulonephritis after exposure to smoked cocaine (crack): A case report and review of the literature. Pathol Int 1997; 47: 692-697
Di Paolo M, Bugelli V, Di Luca A, Turillazzi E. Bladder irrigation and urothelium disruption: A reminder apropos of a case of fatal fluid absorption. BMC Urol 2014; 14: 91
Yamazaki K, Fujita J, Doi I, Abe S, Kawakami Y, Fukazawa Y. A case of acute pulmonary hemorrhage and positive anti-glomerular basement membrane antibody in systemic lupus erythematosus. Nihon Kyobu Shikkan Gakkai Zasshi 1993; 31: 251-256
Yamada T, Mugishima K, Higo S, et al. A case of antiglomerular basement membrane antibody-positive systemic lupus erythematosus with pulmonary hemorrhage successfully treated at an early stage of the disease. J Nippon Med Sch 2018; 85: 138-144
García-Cantón C, Toledo A, Palomar R, et al. Goodpasture's syndrome treated with mycophenolate mofetil. Nephrol Dial Transplant 2000; 15: 920-922.