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Journals / Turkish Journal of Pediatrics / 2020 / Cilt: 62 - Sayı: 6

A rare pediatric case of neurobrucellosis with bilateral optic neuritis

Cengiz HAVALI
Eren ÇAĞAN
Pages
1094–1098
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Isolated optic neuritis is a rare manifestation of neurobrucellosis in children.

📌 3 Key Takeaways

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Objective & Hypothesis:The estimated incidence of central nervous system involvement in brucellosis ranges between 0 and 17.8%.
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Key Findings & Data:An 11-year-old boy presented with the complaint of bilateral visual loss which was more prominent in the left eye than the right.
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Conclusion & Impact:Isolated optic neuritis is a rare manifestation of neurobrucellosis in children.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Background. The estimated incidence of central nervous system involvement in brucellosis ranges between 0 and 17.8%. Optic neuritis is infrequently seen in the clinical presentation of neurobrucellosis. Only six cases of neurobrucellosis manifesting with optic neuritis have been previously reported in the literature during childhood. Moreover, four of these were isolated optic neuritis.Case. An 11-year-old boy presented with the complaint of bilateral visual loss which was more prominent in the left eye than the right. He was diagnosed with brucellosis two months prior. His fundus examination revealed mild papilledema of the right eye and remarkable papilledema of the left eye. Brucella agglutination titer of serum was 1/640. Cerebrospinal fluid (CSF) cultures were negative, but polymerase chain reaction (PCR) examination in CSF was positive for Brucella melitensis. Antibiotic and pulse methylprednisolone treatments were administered. The visual acuity returned incompletely within the 12-month follow-up period.Conclusion. Isolated optic neuritis is a rare manifestation of neurobrucellosis in children.

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Cite This Article

HAVALI, C., ÇAĞAN, E. (2020). A rare pediatric case of neurobrucellosis with bilateral optic neuritis. Turkish Journal of Pediatrics, Cilt: 62 - Sayı: 6, 1094–1098. https://ajindex.com/articles/412069

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References (15)

  1. Hekmatimoghaddam S, Sadeh M, Khalili MB, Mollaabedin M, Sazmand A. Comparison of PCR, Wright agglutination test and blood culture for diagnosis of brucellosis in suspected patients. Pak J Biol Sci 2013; 16: 1589-1592
  2. Mantur BG, Akki AS, Mangalgi SS, Patil SV, Gobbur RH, Peerapur BV. Childhood brucellosis--a microbiological, epidemiological and clinical study. J Trop Pediatr 2004; 50: 153-157
  3. TC. Sağlık Bakanlığı Istatistikler/Temel Sağlık Hizmetleri Genel Müdürlüğü Çalışma Yıllığı. (Available from https://hsgm.saglik.gov.tr/tr/ zoonotikvektorel-bruselloz/istatistik) (Cited 7 July 2020)
  4. Lubani MM, Dudin KI, Araj GF, Manandhar DS, Rashid FY. Neurobrucellosis in children. Pediatr Infect Dis J 1989; 8: 79-82
  5. Yetkin MA, Bulut C, Erdinc FS, Oral B, Tulek N. Evaluation of the clinical presentations in neurobrucellosis. Int J Infect Dis 2006; 10: 446-452
  6. Rolando I, Olarte L, Vilchez G, et al. Ocular manifestations associated with brucellosis: a 26-year experience in Peru. Clin Infect Dis 2008; 46: 1338- 1345
  7. Yeh EA, Graves JS, Benson LA, Wassmer E, Waldman A. Pediatric optic neuritis. Neurology 2016; 87(9 Suppl 2): S53-S58
  8. Dell’Avvento S, Sotgiu MA, Manca S, Sotgiu G, Sotgiu S. Epidemiology of multiple sclerosis in the pediatric population of Sardinia, Italy. Eur J Pediatr 2016; 175: 19-29 9. Karakurum Goksel B, Yerdelen D, Karatas M, et al. Abducens nerve palsy and optic neuritis as initial manifestation in brucellosis. Scand J Infect Dis 2006; 38: 721-725
  9. Tali ET, Keskin T, Oznur, II, Simonson T, Yuh WT. MRI of brucella polyneuritis in a child. Neuroradiology 1996; 38(Suppl 1): S190-S192
  10. Karapinar B, Yilmaz D, Vardar F, Demircioglu O, Aydinok Y. Unusual presentation of brucellosis in a child: acute blindness. Acta Paediatr 2005; 94: 378- 380
  11. Marques R, Martins C, Machado I, Monteiro JP, Campos N, Calhau P. Unilateral optic neuritis as a presentation of neurobrucellosis. Pediatr Rep 2011; 3: e11
  12. Tonekaboni SH, Karimi A, Armin S, Khase LA, Sabertehrani AS. Neurobrucellosis: a partially treatable cause of vision loss. Pediatr Neurol 2009; 40: 401-403
  13. Cavallaro N, Randone A, La Rosa L, Mughinin L. Bilateral papilledema in a patient with brucellosis. Metab Pediatr Syst Ophthalmol (1985). 1990; 13: 115- 118
  14. Abd Elrazak M. Brucella optic neuritis. Arch Intern Med 1991; 151: 776-778
  15. Erdem H, Ulu-Kilic A, Kilic S, et al. Efficacy and tolerability of antibiotic combinations in neurobrucellosis: results of t