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Journals / Turkish Journal of Pediatrics / 2020 / Cilt: 62 - Sayı: 6

Clitoromegaly caused by ovarian stimulation in a preterm newborn: ovarian hyperstimulation syndrome of preterm babies

Elvan BAYRAMOĞLU
Şenay ERDEVE SAVAŞ
Semra ÇETİNKAYA
Zehra AYCAN
Betül Emine DERİNKUYU
İstemi Han ÇELİK
Pages
1088–1093
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This is the first case of POHS developing pericardial effusion.

📌 3 Key Takeaways

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Objective & Hypothesis:Preterm ovarian hyperstimulation syndrome (POHS) is an uncommon disorder characterized by prematurity, hypogastric and upper leg swelling, high serum estradiol and gonadotropin levels, and ovarian cysts.
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Key Findings & Data:A preterm baby who was born at 24 gestational weeks was referred to our clinic for ambiguous genitalia on day 118 of life.
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Conclusion & Impact:This is the first case of POHS developing pericardial effusion.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Background. Preterm ovarian hyperstimulation syndrome (POHS) is an uncommon disorder characterized by prematurity, hypogastric and upper leg swelling, high serum estradiol and gonadotropin levels, and ovarian cysts. Immaturity of the gonadal axis is accepted as the cause. But still, other etiological factors are suspected.Case. A preterm baby who was born at 24 gestational weeks was referred to our clinic for ambiguous genitalia on day 118 of life. Labia majora and clitoris was edematous. Clitoris length was 1.5 cm. On laboratory evaluation: 17OH-Progesterone: 1.84 ng/ml, dehydroepiandrosterone sulphate (DHEA-S): 139 µg/dl, total testosterone (T.T): 88 ng/dl, luteinizing hormone (LH): 22.5 mIU/l, Follicle stimulating hormone (FSH): 15.7 mIU/l, estradiol (E2): 447 pg/ml. Karyotype analysis was 46, XX. There was a 25x14x12 mm ovarian cyst detected on ultrasound. On follow-up, E2 levels and cyst size increased, and there was 4 mm pericardial effusion on echocardiography at the time. Conclusion. In this paper, we present a case with POHS and to discuss possible pathophysiological mechanisms and treatment. This is the first case of POHS developing pericardial effusion.

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Cite This Article

BAYRAMOĞLU, E., SAVAŞ, Ş. E., ÇETİNKAYA, S., AYCAN, Z., DERİNKUYU, B. E., ÇELİK, İ. H. (2020). Clitoromegaly caused by ovarian stimulation in a preterm newborn: ovarian hyperstimulation syndrome of preterm babies. Turkish Journal of Pediatrics, Cilt: 62 - Sayı: 6, 1088–1093. https://ajindex.com/articles/411971

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