SavedAdd your journal

Journals / Turkish Journal of Pediatrics / 2019 / Cilt: 61 - Sayı: 1

Is serum procalcitonin level a reliable indicator in early diagnosis of congenital pneumonia?

Davut BOZKAYA
Şule YİĞİT
Murat YURDAKÖK
Pages
34–39
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Result of this study shows that procalcitonin is an important early markerin the diagnosis of congenital pneumonia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The clinical signs in congenital pneumonia mimic other conditions like transienttachypnea of the newborn (TTN) and respiratory distress syndrome (RDS).Differential diagnosis is difficult since laboratory findings have limited value.Procalcitonin (PCT) is an important and widely studied marker of infection.The aim of this study was to determine the diagnostic value of PCT innewborn patients hospitalized in the neonatal intensive care unit (NICU)with the diagnosis of congenital pneumonia.The infants with respiratory distress who were born at Hacettepe Universitybetween 2005-2015 and hospitalized in the NICU were included in the study.A total of 200 newborn infants; 54 (27%) infants with congenital pneumonia(Group-1), 42 (21%) infants with TTN (Group-2), 40 (20%) infants withRDS (Group-3) and 64 (32%) healthy infants (group-4), were included in thestudy.
📊
Key Findings & Data:There was no statistically significant difference between the groups forserum C-reactive protein (CRP) levels, sampling time for PCT and CRP andthe characteristics of the mother (p> 0.05).
💡
Conclusion & Impact:Result of this study shows that procalcitonin is an important early markerin the diagnosis of congenital pneumonia.
🔬Design:Research Article
📍Scope:2005-2015 Verileri
⚙️Variables:Domain Parameters

Özet

The clinical signs in congenital pneumonia mimic other conditions like transienttachypnea of the newborn (TTN) and respiratory distress syndrome (RDS).Differential diagnosis is difficult since laboratory findings have limited value.Procalcitonin (PCT) is an important and widely studied marker of infection.The aim of this study was to determine the diagnostic value of PCT innewborn patients hospitalized in the neonatal intensive care unit (NICU)with the diagnosis of congenital pneumonia.The infants with respiratory distress who were born at Hacettepe Universitybetween 2005-2015 and hospitalized in the NICU were included in the study.A total of 200 newborn infants; 54 (27%) infants with congenital pneumonia(Group-1), 42 (21%) infants with TTN (Group-2), 40 (20%) infants withRDS (Group-3) and 64 (32%) healthy infants (group-4), were included in thestudy. There was no statistically significant difference between the groups forserum C-reactive protein (CRP) levels, sampling time for PCT and CRP andthe characteristics of the mother (p> 0.05). Mean serum PCT level was higherin the congenital pneumonia group than in the other groups (p< 0.001). Result of this study shows that procalcitonin is an important early markerin the diagnosis of congenital pneumonia.

🔖

Cite This Article

BOZKAYA, D., YİĞİT, Ş., YURDAKÖK, M. (2019). Is serum procalcitonin level a reliable indicator in early diagnosis of congenital pneumonia?. Turkish Journal of Pediatrics, Cilt: 61 - Sayı: 1, 34–39. https://ajindex.com/articles/411930

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Nissen MD. Congenital and neonatal pneumonia. Paediatr Respir Rev 2007; 8: 195-203
  2. Duke T. Neonatal pneumonia in developing countries. Arch Dis Child Fetal Neonatal Ed 2005; 90: F211-F219
  3. Barton L, Hodgman JE, Pavlova Z. Causes of death in the extremely low birth weight infant. Pediatrics 1999; 103: 446-451
  4. Feria-Kaiser C, Furuya ME, Vargas MH, Rodriguez A, Cantu MA; Mortality Committee. Main diagnosis and cause of death in a neonatal intensive care unit: Do clinicians and pathologists agree? Acta Paediatr 2002; 91: 453-458
  5. Walsh WF. Neonatal pneumonia. Semin Pediatr Infect Dis 1995; 6: 166-173
  6. Davies PA, Aherne W. Congenital pneumonia. Arch Dis Child 1962; 37: 598-602
  7. Delanghe JR, Speeckaert MM. Translational research and biomarkers in neonatal sepsis. Clin Chim Acta 2015; 451(Pt A): 46-64
  8. Machado JR, Soave DF, da Silva MV, et al. Neonatal sepsis and inflammatory mediators. Mediators Inflamm 2014; 2014: 269681
  9. Park IH, Lee SH, Yu ST, Oh YK. Serum procalcitonin as a diagnostic marker of neonatal sepsis. Korean J Pediatr 2014; 57: 451-456
  10. Lencot S, Cabaret B, Sauvage G, et al. A new procalcitonin cord-based algorithm in early-onset neonatal infection: For a change of paradigm. Eur J Clin Microbiol Infect Dis 2014; 33: 1229-1238
  11. Chiesa C, Pacifico L, Osborn JF, Bonci E, Hofer N, Resch B. Early-onset neonatal sepsis: Still room for improvement in procalcitonin diagnostic accuracy studies. Medicine (Baltimore) 2015; 94: e1230. 12. van Rossum AM, Wulkan RW, Oudesluys-Murphy AM. Procalcitonin as an early marker of infection in neonates and children. Lancet Infect Dis 2004; 4: 620-630
  12. Chiesa C, Pacifico L, Mancuso G, Panero A. Procalcitonin in pediatrics: Overview and challenge. Infection 1998; 26: 236-241
  13. Bonac B, Derganc M, Wraber B, Hojker S. Interleukin-8 and procalcitonin in early diagnosis of early severe bacterial infection in critically ill neonates. Pflugers Arch Eur J Physiol 2000(Suppl 5); 440: R72-R74
  14. Fendler WM, Piotrowski AJ. Procalcitonin in the early diagnosis of nosocomial sepsis in preterm neonates. J Paediatr Child Health 2008; 44: 114-118
  15. Kocabas E, Sarikcioglu A, Aksaray N, Seydaoglu G, Seyhun Y, Yaman A. Role of procalcitonin, C-reactive protein, interleukin-6, interleukin-8 and tumor necrosis factor-alpha in the diagnosis of neonatal sepsis. Turk J Pediatr 2007; 49: 7-20
  16. Canpolat FE, Yigit S, Korkmaz A, Yurdakok M, Tekinalp G. Procalcitonin versus CRP as an early indicato