In our patients, malignancy directed therapy was sufficient to treat HLH symptoms both at presentation and at recurrence in the second patient.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Hemophagocytic lymphohistiocytosis (HLH) may precede malignancy, in particular lymphomas and leukemias.
📊
Key Findings & Data:However, the causative factors, appropriate treatment and the prognosis of this association is not established.
💡
Conclusion & Impact:In our patients, malignancy directed therapy was sufficient to treat HLH symptoms both at presentation and at recurrence in the second patient.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
Background. Hemophagocytic lymphohistiocytosis (HLH) may precede malignancy, in particular lymphomas and leukemias. However, the causative factors, appropriate treatment and the prognosis of this association is not established. Case. Herein, we present two patients, one with nodular sclerosing Hodgkin lymphoma (HL) and concomitant Epstein-Barr virus (EBV) infection, and the other with anaplastic large cell lymphoma (ALCL), presented as malignancy associated HLH. Conclusion. In our patients, malignancy directed therapy was sufficient to treat HLH symptoms both at presentation and at recurrence in the second patient.
🔖
Cite This Article
AKSU, T., BAYHAN, T., GÜLHAN, B., ÇAKMAKÇI, S., OĞUZ, A. S., YARALI, N., ÖZBEK, N. Y., İLHAN, İ. E. (2020). Children with lymphoma presenting with hemophagocytic lymphohistiocytosis. Turkish Journal of Pediatrics, Cilt: 62 - Sayı: 2, 284–288. https://ajindex.com/articles/411925
Shimada A, Kato M, Tamura K, et al. Hemophagocytic lymphohistiocytosis associated with uncontrolled inflammatory cytokinemia and chemokinemia was caused by systemic anaplastic large cell lymphoma: a case report and review of the literature. J Pediatr Hematol Oncol 2008; 30: 785-787
Henter JI, Horne A, Arico M, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007; 48: 124-131
Jordan MB, Allen CE, Weitzman S, Filipovich AH, Mcclain LK. How I treat hemophagocytic lymphohistiocytosis. Blood 2011; 118: 4041-4052
Lehmberg K, Sprekels B, Nichols KE, et al. Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents. Br J Haematol 2015; 170: 539-549
Daver N, McClain K, Allen CE, et al. A consensus review on malignancy-associated hemophagocytic lymphohistiocytosis in adults. Cancer 2017; 123: 3229-3240
Zhang K, Jordan MB, Marsh RA, et al. Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH. Blood 2011; 118: 5794-5798
Ciambotti B, Mussolin L, d'Amore ESG, et al. Monoallelic mutations of the perforin gene may represent a predisposing factor to childhood anaplastic large cell lymphoma. J Pediatr Hematol Oncol 2014; 36: e359-e365
Strenger V, Merth G, Lackner H, et al. Malignancy and chemotherapy induced haemophagocytic lymphohistiocytosis in children and adolescents-a single centre experience of 20 years. Ann Hematol 2018; 97: 989-998
Hagihara M, Inoue M, Hua J, Iwaki Y. Lymphocytedepleted Hodgkin lymphoma complicating hemophagocytic lymphohistiocytosis as an initial manifestation: a case report and review of the literature. Intern Med 2012; 51: 3067-3072
Abaza H, Ben Chaabene A, Sallami S, Boussen H, Rahal K, Guemira F. Hemophagocytic syndrome associated to a Hodgkin lymphoma. Tunis Med 2015; 93: 399-400
Chan K, Behling E, Strayer DS, Kocher WS, Dessain SK. Prolonged hemophagocytic lymphohistiocytosis syndrome as an initial presentation of Hodgkin lymphoma: a case report. J Med Case Rep 2008; 2: 367
Dominguez-Munoz MA, Morales-Camacho RM, Prats-Martin C, et al. Unusual co-occurrence of Hodgkin lymphoma and hemophagocytic lymphohistiocytosis in a bone marrow aspirate. Ann Hematol 2016; 95: 1019-1021
Ichikawa S, Takahashi T, Katsushima H, Fukuhara N, Ichinohasama R, Harigae H. Advanced lymphocyterich classical Hodgkin lymphoma complicated with fatal hemophagocytic syndrome. Int