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Journals / Turkish Journal of Gastroenterology / 2022 / Cilt: 33 - Sayı: 2

The Predictive Value of Periostin to Diagnose Crohn’s Disease

MUHARREM KESKİN
Ali TOPKAÇ
Pages
127–135
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Serum periostin levels of the patients followed up with the diagnosis of Crohn’s disease in remission were found to be significantly higher than the healthy individuals, and cut-off values of serum periostin were obtained to both diagnose Crohn’s disease and predict the course of the disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: There is still no sensitive and specific biomarker that can be used in the diagnosis and follow-up of Crohn’s disease, so we aimed to assess the diagnostic accuracy of serum periostin levels in Crohn’s disease.
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Key Findings & Data:Methods: The study included 40 Crohn’s disease patients aged 18-70 years and considered in remission (Crohn’s Disease Activity Index 8 years according to the follow-up period (in the group 8 years compared to the control group (P < .001, P < .001, P = .038, respectively).
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Conclusion & Impact:Conclusion: Serum periostin levels of the patients followed up with the diagnosis of Crohn’s disease in remission were found to be significantly higher than the healthy individuals, and cut-off values of serum periostin were obtained to both diagnose Crohn’s disease and predict the course of the disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Background: There is still no sensitive and specific biomarker that can be used in the diagnosis and follow-up of Crohn’s disease, so we aimed to assess the diagnostic accuracy of serum periostin levels in Crohn’s disease. Methods: The study included 40 Crohn’s disease patients aged 18-70 years and considered in remission (Crohn’s Disease Activity Index 8 years according to the follow-up period (in the group 8 years compared to the control group (P < .001, P < .001, P = .038, respectively). For the diagnosis of Crohn’s disease independent of disease duration, the cut-off periostin level was determined as 27.8 ng/mL, while the sensitivity and specificity for this value were 72.5% and 77.5%, respectively. Conclusion: Serum periostin levels of the patients followed up with the diagnosis of Crohn’s disease in remission were found to be significantly higher than the healthy individuals, and cut-off values of serum periostin were obtained to both diagnose Crohn’s disease and predict the course of the disease.

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Cite This Article

KESKİN, M., TOPKAÇ, A. (2022). The Predictive Value of Periostin to Diagnose Crohn’s Disease. Turkish Journal of Gastroenterology, Cilt: 33 - Sayı: 2, 127–135. https://ajindex.com/articles/411633

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