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Journals / Turkish Journal of Obstetrics and Gynecology / 2021 / Cilt: 18 - Sayı: 4

Artmış maternal parkinson hastalığı proteini 7 düzeyinin preterm prematür membran rüptürü ile ilişkisi - Prospektif randomize bir çalışma

The association between increased maternal PARK7 (DJ-1) levels and the occurrence of preterm premature rupture of membranes - A randomized prospective study

UĞUR TURHAN
Burak TATAR
Pages
279–284
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Daha geniş çalışmalara ihtiyaç vardır.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Amaç: Parkinson hastalığı protein 7 (PARK7) enflamasyon ve oksidatif strese karşı önemli bir antioksidan multiproteindir.
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Key Findings & Data:Bu çalışmayı preterm prematüre membran rüptürü (PPROM) hastalarında maternal PARK (DJ-1) düzeyini araştırmak için tasarladık.
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Conclusion & Impact:Daha geniş çalışmalara ihtiyaç vardır.
🔬Design:Research Article
📍Scope:80 hasta
⚙️Variables:Domain Parameters

Abstract

Amaç: Parkinson hastalığı protein 7 (PARK7) enflamasyon ve oksidatif strese karşı önemli bir antioksidan multiproteindir. Bu çalışmayı preterm prematüre membran rüptürü (PPROM) hastalarında maternal PARK (DJ-1) düzeyini araştırmak için tasarladık. Gereç ve Yöntemler: Kesitsel çalışmaya 24-36. gebelik haftaları arasında 50 PPROM ve 30 sağlıklı kontrol hastası olmak üzere toplamda 80 hasta dahil edildi. Enzim-Bağlı immünosorbent tahlili yöntemiyle maternal serum PARK 7 seviyeleri ölçüldü. Bulgular: PPROM hastalarında sağlıklı kontrollere göre plazma PARK7 düzeyleri daha yüksekti (p<0,001). PARK7, kanda lökosit düzeyleri (p<0,001), CRP düzeyleri (p<0,001) ile pozitif, doğum ağırlığı ve doğum haftası ile negatif korelasyon gösterdi. Sonuç: PARK 7, PPROM hastalarında aşırı eksprese edilmektedir. Anti-enflamatuvar ve antioksidan özelliklerinden dolayı PARK7, PPROM patofizyolojisini ve prognozunu öngörmede yeni bir belirteç olabilir. Daha geniş çalışmalara ihtiyaç vardır.

Özet

Objective: Parkinson’s disease protein 7 (PARK7/DJ-1) is an important antioxidant multiprotein against inflammation and oxidative stress. We therefore planned this study to demonstrate the association between maternal PARK7 levels and the occurrence of preterm premature rupture of membranes (PPROM). Materials and Methods: We enrolled 80 pregnant women; 50 PPROM patients and 30 healthy controls, into this cross- sectional study between the 24th and 36th gestational weeks. Furthermore, we measured serum PARK 7 levels using enzyme-Linked immunosorbent assay method. Results: Plasma PARK7 levels were higher in PPROM patients compared to those in the healthy controls (p<0.001). With a cutoff value of 2.57 pg/mL; PARK 7 had a 92% sensitivity, 86% specificity, 88% positive predictive value and 83% negative predictive value (p<0.01) for PPROM. PARK7 had positive correlation with blood leukocyte levels (p<0.001), C-reactive protein levels (p<0.001), and negatively correlated with birth weight and birth week. Conclusion: PARK 7 is overexpressed in PPROM patients. Due to its anti-inflammatory and antioxidant properties, PARK7 may be a novel marker in better understanding the pathophysiology and prediction of the prognosis PPROM. Further large-scale studies are needed.

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Cite This Article

TURHAN, U., TATAR, B. (2021). Artmış maternal parkinson hastalığı proteini 7 düzeyinin preterm prematür membran rüptürü ile ilişkisi - Prospektif randomize bir çalışma. Turkish Journal of Obstetrics and Gynecology, Cilt: 18 - Sayı: 4, 279–284. https://ajindex.com/articles/411600

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