Journals / Turkish Journal of Gastroenterology / 2010 / Cilt: 21 - Sayı: 4

Safra kesesi taşlarının non-alkolik steatohepatit ve metabolik sendromla birlikteliği

Gallstones associated with nonalcoholic steatohepatitis (NASH) and metabolic syndrome

Pages
411–415
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The high prevalence of non-alcoholic steatohepatitis in patients with galbladder stone may justify routine liver biopsy during cholecystectomy to establish the diagnosis and stage and possibly direct therapy.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aims: We aimed to evaluate the prevalence of non-alcoholic steatohepatitis and metabolic syndrome in patients with symptomatic gallstones undergoing laparoscopic or open cholecystectomy.
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Key Findings & Data:Methods: A study of 95 patients was performed.
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Conclusion & Impact:The high prevalence of non-alcoholic steatohepatitis in patients with galbladder stone may justify routine liver biopsy during cholecystectomy to establish the diagnosis and stage and possibly direct therapy.
🔬Design:Research Article
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Background/aims: We aimed to evaluate the prevalence of non-alcoholic steatohepatitis and metabolic syndrome in patients with symptomatic gallstones undergoing laparoscopic or open cholecystectomy. Methods: A study of 95 patients was performed. Simultaneous liver biopsies were taken during cholecystectomy between 2006 and 2007. There were no postoperative complications. Patients with significant alcohol intake, hepatitis B or C (virus-positive), autoimmune diseases, and Wilson's disease were excluded. Demographics, liver function tests, lipid profile, and ultrasound findings of patients with and without non-alcoholic steatohepatitis were compared. Results: A total of 95 patients completed the study. The mean age was 52.15 years, and 29 patients were male and 66 female. Fifty-two patients (55%) had biopsies compatible with non-alcoholic steatohepatitis. Conclusions: Fifty-five percent of patients with gallbladder stones had associated non-alcoholic steatohepatitis. Awareness of this association may result in an earlier diagnosis. The high prevalence of non-alcoholic steatohepatitis in patients with galbladder stone may justify routine liver biopsy during cholecystectomy to establish the diagnosis and stage and possibly direct therapy.

Özet

Amaç: Bu çalışmada semptomatik safra kesesi taşı nedeniyle açık veya laparoskpopik kolesistektomi yapılan hastalarda NASH ve metabolik sendromun sıklığını değerlendirmek amaçlanmıştır. Yöntem: 2006 2007 tarihleri arasında 95 hastadan kolesistektomi esnasında karaciğer biopsisi alınmıştır. Postoperatif komplikasyon oluşmamıştır. Alkol alımı, HBV HCV otoimmün hastalıklar ve Wilson hastalığı çalışma kapsamı dışına alınmıştır. Hasta demografik bulguları karaciğer testleri lipid profili ve ultrason bulguları NASH olan ve olmayan grupta karşılaştırtılmıştır. Bulgular: Toplam 95 hasta çalışmaya alınmıştır. Ortalama yaş 52.15 olup 29 hasta erkek 66 hasta kadındı. 55 hastanın biopsisi NASH ile uyumluydu. Sonuç: Safra taşı olan 55 hastada NASH saptanmıştır. Bu birlikteliğin erken dönemde farkına varılmalıdır. NASH safra taşlarıyla yüksek oranda birlikteliği nedeniyle kolesistektomi esnasında rutin karaciğer biopsisi teşhis tedavi açısından önemlidir.

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Cite This Article

YENER, O., AKSOY, F., DEMİR, M., ÖZÇELİK, A., ERENGÜL, C. (2010). Safra kesesi taşlarının non-alkolik steatohepatit ve metabolik sendromla birlikteliği. Turkish Journal of Gastroenterology, Cilt: 21 - Sayı: 4, 411–415. https://ajindex.com/articles/411477

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