Journals / Turkish Journal of Gastroenterology / 2012 / Cilt: 23 - Sayı: 2

Sağ hepatektomi öncesinde değişik ajanlarla yapılan portal ven embolizasyonu

Portal vein embolization with different embolic agents for right hepatectomy

Pages
148–155
DOI
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AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, randomized, controlled studies with hypertrophy- inducing agents are needed.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aims: We aimed to retrospectively evaluate our experience in portal vein embolization that induces hypertrophy of the future liver remnant before right hepatectomy and to determine the differences in outcome with respect to the embolic agents used.
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Key Findings & Data:Methods: Twenty right portal vein embolization procedures performed in our institution between 2004 and 2009 were reviewed in this study.
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Conclusion & Impact:However, randomized, controlled studies with hypertrophy- inducing agents are needed.
🔬Design:Review & Systematic Survey
📍Scope:2004 Verileri
⚙️Variables:Domain Parameters

Abstract

Background/aims: We aimed to retrospectively evaluate our experience in portal vein embolization that induces hypertrophy of the future liver remnant before right hepatectomy and to determine the differences in outcome with respect to the embolic agents used. Methods: Twenty right portal vein embolization procedures performed in our institution between 2004 and 2009 were reviewed in this study. The average patient age was 59 years (range: 45-72 years). Embolization was performed through a right portal vein percutaneous access with use of the combination of several agents. Computed tomography volumetry was performed before and 4-6 weeks after the procedure to measure total liver volume and future liver remnant. Results: There was no major complication related to the embolization procedures. After embolization, future liver remnant/total liver volume ratio increased to 12.7%, which was statistically significant. No significant difference was noted in hypertrophic outcomes between alcohol and the other embolic agents. Although five patients had sufficient future liver remnant, they did not undergo subsequent hepatectomy for a variety of reasons. Conclusions: According to our results, the mean increase in the size of the future liver remnant was greater than reported in previous studies of portal vein embolization. Despite the limited patient number of our study, we believe that portal vein embolization is helpful especially in gray-zone patients who may be a good candidate for surgical resection and thus possible cure. However, randomized, controlled studies with hypertrophy- inducing agents are needed.

Özet

Amaç: Bu çalışmada sağ hepatektomi öncesinde kalan karaciğer hacmini artırmak için yapılan portal ven embolizasyonu ile ilgili deneyimlerimizi retrospektif olarak sunduk ve farklı embolizan ajanların etkinliğini araştırdık. Yöntem ve Gereç: Bu çalışmada 2004 ve 2009 yılları arasında merkezimizde 20 olguya portal ven embolizasyonu uygulandı. Hastaların ortalama yaşı 59'du (45-72 yaşları arasında). Embolizasyon değişik ajanların kombinasyonu kullanılarak sağ portal vene perkiitan girişimle yapıldı. İşlemden önce ve 4-6 hafta sonra total karaciğer hacmini ve karaciğer hacmini hesaplamak için bilgisayarlı tomografi volümetri yapıldı. Bulgular: İşlemle ilgili major komplikasyon görülmedi. Embolizasyon sonrası karaciğer hacmi'/total karaciğer hacmi oranı 12.7'lere çıktı ve bu istatistiksel olarak anlamlıydı. Alkol ve diğer embolizan ajanlar arasındaki sonuçlarda istatistiksel olarak anlamlı farklılık yoktu. 5 hastada belirgin karaciğer hacmi olmasına rağmen çeşitli nedenlerden dolayı hepatektomiye gidilmedi. Sonuç: Bizim olgularımızda karaciğer hacmi ölçümlerindeki artış daha önceki bildirilen portal ven embolizasyonu çalışmalarından daha fazlaydı. Çalışmamızıla, hasta sayısı az olmasına rağmen portal ven embolizasyonunıın gri zon hastalar içirt cerrahiye iyi bir aday oluşturması ve böylece olası kür sağlaması açısından yardımcı olduğuna inanıyoruz. Bununla birlikte embolizan ajanların karaciğer hacmi artırması ile ilgili kontrollü, randomize çalışmalara ihtiyaç vardır.

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Cite This Article

PEYNİRCİOĞLU, B., ÇİL, B., ÖZKAN, F., KOÇ, O., AKINCI, D., ABBASOĞLU, O., HAMALOĞLU, E., BALKANCI, F. (2012). Sağ hepatektomi öncesinde değişik ajanlarla yapılan portal ven embolizasyonu. Turkish Journal of Gastroenterology, Cilt: 23 - Sayı: 2, 148–155. https://ajindex.com/articles/411474

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References (15)

  1. Ribero D, Abdalla EK, Madoff DC, et al. Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome. Br J Surg 2007; 94: 1386–94
  2. Nagino M, Kamiya J, Nishio H, et al. Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and longterm follow-up. Ann Surg 2006; 243: 364–72
  3. Yokoyoma Y, Nagino M, Nimura Y. Mechanisms of hepatic regeneration following portal vein embolization and partial hepatectomy: a review. World J Surg 2007; 31: 367–74
  4. Madoff DC, Abdalla EK, Vauthey JN. Portal vein embolization in preparation for major hepatic resection: evolution of a new standard of care. J Vasc Interv Radiol 2005; 16: 779–90
  5. Omary RA, Bettmann MA, Cardella JF, et al. Quality improvement guidelines for the reporting and archiving of interventional radiology procedures. J Vasc Interv Radiol 2003; 14: S293–S295
  6. Giraudo G, Gretet M, Oussoultzoglou E, et al. Preoperative contralateral portal vein embolization before major hepatic resection is a safe and efficient procedure: a large single institution experience. Surgery 2008; 143: 476–82
  7. Sugawara Y, Yamamoto J, Higashi H, et al. Preoperative portal embolization in patients with hepatocellular carcinoma. World J Surg 2002; 26: 105–10
  8. Abdalla EK, Barnett CC, Doherty D, et al. Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization. Arch Surg 2002; 137: 675–81
  9. Cotroneo AR, Innocenti P, Marano G, et al. Pre-hepatectomy portal vein embolization: single center experience. Eur J Surg Oncol 2008; 7: 1–8
  10. Hemming AW, Reed AI, Howard RJ, et al. Preoperative portal vein embolization for extended hepatectomy. Ann Surg 2003; 237: 686–93
  11. Abulkhir A, Limongelli P, Healey AJ, et al. Preoperative portal vein embolization for major liver resection: a metaanalysis. Ann Surg 2008; 247: 49–57
  12. Beal IK, Anthony S, Papadopoulou A, et al. Portal vein embolisation prior to hepatic resection for colorectal liver metastases and the effects of periprocedure chemotherapy. Br J Radiol 2006; 79: 473–8
  13. Ferrero A, Vigano L, Polastri R, et al. Postoperative liver dysfunction and future remnant liver: where is the limit? Results of a prospective study. World J Surg 2007; 31: 1643–51
  14. Yoo H, Ko GY, Gwon DI, et al. Preoperative portal vein embolization using an amplatzer vascular plug. Eur Radiol 2009; 19: 1054–61
  15. Bent CL, Lo