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Journals / Turkish Journal of Gastroenterology / 1999 / Cilt: 10 - Sayı: 1

Helicobacter pylori'ye bağlı gastritis ve duodenum ülserinde omeprazol, amoksisilin ve klaritromisin tedavisinin etkinliği

Efficacy of combination therapy with omeprazole, amoxicillin and clarithromycin for treatment of patients with Helicobacter pylori associated gastritis and duodenal ulcer disease

Yeşim ERALP
Can DAVUTOĞLU
Hülya UZUNİSMAİL
Ergun OKTAY
Pages
27–31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, we have determined that both combination regimens are quite effective and safe for the treatment of H. pylori infection and no significant difference was observed between the two different doses of clarithromycin administered.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study we evaluated the efficacy of a combination therapy with omeprazole, amoxicillin and clarithromycin for treatment of patients with Helicobacter pylori (H. pylori) associated gastritis and duodenal ulcer disease.
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Key Findings & Data:Fifty patients, who were distributed randomly into two groups received two different doses of clarithromycin daily for 15 days, while amoxcillin and omeprazole were administered as 1 gr bid for 15 days and 20 mg. bid for one month respectively.
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Conclusion & Impact:In conclusion, we have determined that both combination regimens are quite effective and safe for the treatment of H. pylori infection and no significant difference was observed between the two different doses of clarithromycin administered.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İlaç tedavisi · kombinasyon · Omeprazol

Abstract

In this study we evaluated the efficacy of a combination therapy with omeprazole, amoxicillin and clarithromycin for treatment of patients with Helicobacter pylori (H. pylori) associated gastritis and duodenal ulcer disease. Fifty patients, who were distributed randomly into two groups received two different doses of clarithromycin daily for 15 days, while amoxcillin and omeprazole were administered as 1 gr bid for 15 days and 20 mg. bid for one month respectively. Patients were called for follow up examinations following six weeks of maintenance treatment with famotidine. All duodenal ulcers were found to be healed completely and gastric activation decreased in both groups after therapy. Eradication rates were 76.2% in the 1st group and 72.4% in the 2nd group, who had received 250 mg. bid and 500 mg. bid clarithromycin, respectively. In conclusion, we have determined that both combination regimens are quite effective and safe for the treatment of H. pylori infection and no significant difference was observed between the two different doses of clarithromycin administered. However, long term usage and higher cost are major drawbacks for this combination threrapy.

Özet

Bu çalışmada Helicobacter pylori (H. pylori)'ye bağlı gastrit ve duodenal ülserli hastalarda omeprazol, amoksisilin ve klaritromisin tedavisinin etkinliği araştırılmıştır. Klaritromisinin günlük dozuna göre 2 gruba ayrılan toplam 50 hastaya 1 ay boyunca omeprazol, son 15 gün amoksisilin ve klaritromisin uygulanmıştır. Tedavinin bitiminden 6 hafta sonra yapılan kontrolde günde 3x250 mg klaritromisin verilen 1. grupta % 76.2, 3x500 mg. klaritromisin verilen 2. grupta ise % 72.4 eradikasyon elde edilmiştir. Aynı zamanda duodenal ülserli tüm hastalarda tedavi ile ülserin iyileştiği ve her iki gruptada gastrit aktivasyonunun azaldığı saptanmıştır. Sonuç olarak her iki tedavi rejimi H. pylori eradikasyonunda etkin ve belirgin bir yan etkiye yol açmaması nedeniyle tercih edilebilecek bir kombinasyondur. Klaritromisinin 1500 mg/gün ve 750 mg/gün olarak uygulanan dozları arasında anlamlı bir fark bulunmamıştır. Ancak uzun süreli kullanım zorunluluğu ve pahalı oluşu, bu tedavi şeklinin dezavantajlarını oluşturmaktadır.

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Cite This Article

ERALP, Y., DAVUTOĞLU, C., UZUNİSMAİL, H., OKTAY, E. (1999). Helicobacter pylori'ye bağlı gastritis ve duodenum ülserinde omeprazol, amoksisilin ve klaritromisin tedavisinin etkinliği. Turkish Journal of Gastroenterology, Cilt: 10 - Sayı: 1, 27–31. https://ajindex.com/articles/411393

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