AI Summary & Key Takeaways
AI InsightThis case report extends the gastroenterological manifestations of the APA syndrome to include colonic ulceration, which may outweigh the efficacy of initial anticoagulant therapy.
📌 3 Key Takeaways
Abstract
The antiphospholipid antibody syndrome (APA) is characterized by an increased incidence of venous and arterial thrombosis. APA syndrome has some gastroenterological manifestations such as Budd-Chiari syndrome, hepatic infarction, esophageal necrosis, intestinal ischemia, pancreatitis and colonic ulceration. We report a 34-year-old man with APA syndrome complicated by hepatic venous thrombosis (Budd-Chiari) and colonic ulcers. The clinical and laboratory findings were compatible with APA syndrome that developed secondary to systemic lupus erythematosus. In order to initiate anticoagulant therapy, he was heparinized. Since lower gastrointestinal bleeding developed, heparin was discontinued and the patient was followed up with baby aspirin and steroids. This case report extends the gastroenterological manifestations of the APA syndrome to include colonic ulceration, which may outweigh the efficacy of initial anticoagulant therapy.
Özet
Antifosfolipid antikor sendromu (AFA), artmış venöz ve arteriyel tromboz insidansı ile karakterize bir sendromdur. AFA sendromununı; Budd-Chiari sendromu, hepatik iskemi, özofagus nekrozu, intestinal iskemi, pankreatit ve kolon ülserleri gibi gastrointestinal sistem yansımaları bulunmaktadır. Burada; hepatik venöz tromboz (Budd-Chiari) ve kolon ülserleri ile karakterize AFA sendromlu 34 yaşında erkek olgu sunuldu. Olgunun klinik ve laboratuar bulguları SLE’ye sekonder gelişen AFA sendromu ile uyumlu idi. Hastaya antikoagülan tedavi amacıyle heparinizasyon uygulandı. Alt gastrointestinal sistem kanaması gelişmesi üzerine heparinizasyon sonlandırıldı ve yerine aspirin ve steroid tedavisi başlandı. Bu olgu; AFA sendromunun kolonik ülserlerle seyreden ve antikoagülan tedavi etkinliğinin fazla oranda gözlendiği bir olgudur.