Journals / Turkish Journal of Gastroenterology / 2000 / Cilt: 11 - Sayı: 3

Midenin hepatoid adenokarsinomu: Üç vakanın histopatolojik ve immünohistokimyasal analizi

Hepatoid adenocarcinoma of the stomach: Histopathologic and immunohistochemical analysis of three cases

Pages
255–259
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Nonneoplastic mucosa of the stomach showed chronic atrophic gastritis and various degrees of intestinal metaplasia.

📌 3 Key Takeaways

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Objective & Hypothesis:Hepatoid adenocarcinoma of the stomach is a special form of gastric carcinoma with both adenocarcinomatous and hepatocellular differentiation.
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Key Findings & Data:In our cases, all tumors had demonstrated an aggressive growth pattern and there was extensive angiolymphatic invasion.
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Conclusion & Impact:Nonneoplastic mucosa of the stomach showed chronic atrophic gastritis and various degrees of intestinal metaplasia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Adenokarsinom · Erişkin · Yaşlı

Abstract

Hepatoid adenocarcinoma of the stomach is a special form of gastric carcinoma with both adenocarcinomatous and hepatocellular differentiation. Periodic acid-Schiff positive hyaline globules and immunohistochemically positive reactivity of alpha-fetoprotein are the main characteristics of the tumor. In this study, three gastric carcinomas diagnosed as hepatoid adenocarcinoma are presented. In our cases, all tumors had demonstrated an aggressive growth pattern and there was extensive angiolymphatic invasion. We found periodic acid-Schiff positive hyaline globules and alphafetoprotein reactivity in these tumors. In two cases, lymph node metastases were present. Nonneoplastic mucosa of the stomach showed chronic atrophic gastritis and various degrees of intestinal metaplasia.

Özet

Midenin hepatoid adenokarsinomu, hem adenokarsinom hem de hepatoid diferansiasyon gösteren özel bir mide karsinomu tipidir. Tümörün temel özelliği periodik asid-Schiff pozitif hyalin globüller ve immünohistokimyasal olarak alfa-fetoproteinreaktivitesidir. Bu çalışmada hepatoid adenokarsinom tanısı alan üç mide karsinomu olgusunu inceledik. Bütün olgularımızda tümörler invazif bir gelişim manzarasına sahipti ve yaygın anjiolenfatik invazyon vardı. Bu tümörlerde periodik asid-schiff pozitif hyalin globülleri ve alfafetoprotein reaktivitesini gösterdik. İki olguda lenf nodu metastazı tesbit edildi. Her üç olguda da neoplastik olmayan mide mukozası, kronik atrofik gastrit ve değişen yaygınlıkta intestinal metaplazi gösteriyordu

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Cite This Article

ARAR, M., PATIROĞLU, T. E., KONTAŞ, O., TEKİN, Y. (2000). Midenin hepatoid adenokarsinomu: Üç vakanın histopatolojik ve immünohistokimyasal analizi. Turkish Journal of Gastroenterology, Cilt: 11 - Sayı: 3, 255–259. https://ajindex.com/articles/411271

References (1)

  1. Ishikura H, Fukosawa Y, Ogosawara K, et al. An AFP-producing gastric carcinoma with features of hepatic differentiation: A case report. Cancer 1985; 56: 840-8. 2). Roberts CC, Colby TV, Batts KP. Carcinoma of the stomach with hepatocyte differentiation (Hepatoid adenocarcinoma). Mayo Clin Proc 1997; 72: 1154-60. 3). Ishikura H, Kirimoto K, Shamoto M, et al. Hepatoid adenocarcinoma of the stomach. An analysis of seven cases. Cancer 1986; 58: 119-26. 4). Gitlin D, Perricelli A, Gitlin GM. Synthesis of alpha-fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res 1972; 32: 979-82. 5). Ooi A, Nakanishi I, Sakamoto N, et al. Alpha-Fetoprotein (AFP) producing gastric carcinoma. Is it hepatoid differentiation? Cancer 1990; 65:1741-7. 6). Nagai E, Ueyama T, Yao T, et al. Hepatoid adenocarcinoma of the stomach. A clinicopathologic and immunohistochemical analysis. Cancer 1993; 72: 1827-35. 7). Okamoto T. Comparative morphology of endodermal sinus tumor( Teilum) to human yolk sac and a proposal of endodermal cell tumor. Acta Pathol Jpn 1983; 33: 1-14. 8). Yachinin S. The immunosupressive properties of alpha-feto protein: A brief overview. Ann NY Acad Sci 1983; 417: 105-7. 9). Borrmann R. Geschwülste des Magens und duedonums. In Henske F, Lubarsch O, eds: Handbuch der Speziellen Pathologischen Antomie und Histologie. Julius Springer, Berlin 1926. 10). Lauren P. The two histological main types of gastric carcinoma. Diffuse and so-called intestinal type carcinoma. Acta Pathol Microbiol Scand 1965; 64: 31-49.