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Journals / Turkish Journal of Gastroenterology / 2000 / Cilt: 11 - Sayı: 2

Helicobacter pylori ve antibiyotik direnci

Helicobacter pylori and antibiotic resistance

Bülent KANTARÇEKEN
Bülent YILDIRIM
Melih KARINCAOĞLU
Murat ALADAĞ
Fatih HİLMİOĞLU
Pages
141–145
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The high resistance rates to antibiotics, especially metronidazole and clarithromycin, in our study is likely to originate from their widespread and inappropriate use at insufficient

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aims: This study investigated resistance rates to anibiotics commonly used to treat Helicobacter pylori.
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Key Findings & Data:Methods: Helicobacter pylori isolates from gastric antral biopsy cultures of 51 patients, admitted to our gastroenterology department for upper gastrointestinal system complaints, were examined for sensitivity to amoxicillin, metronidazole, clarithromycin, tetracycline and ciprofloxacin by disk diffusion method.
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Conclusion & Impact:The high resistance rates to antibiotics, especially metronidazole and clarithromycin, in our study is likely to originate from their widespread and inappropriate use at insufficient
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İlaç direnci · mikrobiyal · Mikrobiyal duyarlılık testleri

Abstract

Background/Aims: This study investigated resistance rates to anibiotics commonly used to treat Helicobacter pylori. Methods: Helicobacter pylori isolates from gastric antral biopsy cultures of 51 patients, admitted to our gastroenterology department for upper gastrointestinal system complaints, were examined for sensitivity to amoxicillin, metronidazole, clarithromycin, tetracycline and ciprofloxacin by disk diffusion method. Results: Twentynine patients (57%) were resistant to antibiotics, while 22 patients (43%) showed no resistance. Resistance to metronidazole, clarithromycin, tetracycline and ciprofloxacin was found in 25 (49%), five (9.8%), two (3.9%) and three patients (5.9%) respectively. Conclusions: No resistance to amoxicillin was seen. The high resistance rates to antibiotics, especially metronidazole and clarithromycin, in our study is likely to originate from their widespread and inappropriate use at insufficient

Özet

Amaç: Helicobacter pylori tedavisinde sıklıkla kullanılan antibiyotiklere karşı oluşan direnç oranları araştırıldı. Yöntem: Gastroenteroloji kliniğimize üst gastrointestinal sistem şikayetleri ile başvuran 51 hastanın mide antral biyopsi kültürlerinden izole edilen Helicobacter pylori suşlarının amoksisilin, metronidazol, klaritromisin, tetrasiklin ve siprofloksasin'e duyarlılığı disk difüzyon yöntemi ile incelendi. Bulgular: Hastaların 29'unda (%57) antibiyotiklere karşı direnç saptanırken 22(%43) hastada antibiyotik direnci gözlenmedi. Metronidazol'e 25 hastada (%49), klaritromisin'e 5 hastada (%9.8), Tetrasiklin'e 2 hastada (%3.9), siprofloksasin'e 3 hastada (%5.9) direnç saptanırken amoksisilin'e karşı direnç gözlenmedi. Sonuç: Başta metronidazol ve klaritromisin olmak üzere, antibiyotikler için bulunan yüksek direnç oranları muhtemelen bu ilaçların yetersiz süre ve dozlarda gelişigüzel ve yaygın olarak kullanılmasından kaynaklanmaktadır.

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Cite This Article

KANTARÇEKEN, B., YILDIRIM, B., KARINCAOĞLU, M., ALADAĞ, M., HİLMİOĞLU, F. (2000). Helicobacter pylori ve antibiyotik direnci. Turkish Journal of Gastroenterology, Cilt: 11 - Sayı: 2, 141–145. https://ajindex.com/articles/411246

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