Journals / Turkish Journal of Gastroenterology / 2001 / Cilt: 12 - Sayı: 2

Pilor stenozu tedavisinde asit azaltıcı ve anti-Helicobacter tedavi: Bir prospektif çalışma

Acid reduction and Helicobacter pylori treatment in pyloric stenosis: A prospective study

Pages
122–125
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Surgery and endoscopic dilation should only be performed in cases of treatment failure.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aims: Surgery and endoscopic balloon dilation are the most frequent approaches for the treatment of gastric outlet obstruction due to peptic ulcer disease.
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Key Findings & Data:Methods: Between 1994 and 1999 12 consecutive patients with pyloric stenosis were studied.
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Conclusion & Impact:Surgery and endoscopic dilation should only be performed in cases of treatment failure.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Helicobacter enfeksiyonları · Proton pompası · Pilor stenozu

Abstract

Background/Aims: Surgery and endoscopic balloon dilation are the most frequent approaches for the treatment of gastric outlet obstruction due to peptic ulcer disease. Recent reports have shown that antacids plus anti-Helicobacter pylori treatment may resolve peptic stenosis. Methods: Between 1994 and 1999 12 consecutive patients with pyloric stenosis were studied. Four were prescribed omeprazole 40 mg bid, ornidazole 500mg bid, colloidal bismuth subcitrate 600 mg bid and amoxicillin 500mg bid for two weeks, followed by omeprazole for four weeks. Six patients were given lansoprazole 30mg bid, clarithromycin 500mg bid and ampicillin 1gr bid for one week, followed by lansoprazole for four weeks. Two patients were given lansoprazole 30 mg/d clarithromycin 500 mg bid and amoxicillin 1 g bid for one week, followed by lansoprazole 30 mg/day for six weeks. All patients except one underwent endoscopy four, eight and 24 months after the first endoscopy, following which three patients underwent this procedure after and year, one patient after three years one four patients after four years. Results: Pyloric stenosis improved in all patients except one who underwent follow-up endoscopy four weeks after initial diagnosis. In one patient, symptoms were not relieved after one week of the above treatment so nasogastric aspirat›on and surgery was performed. No ulcer or stenosis was observed on follow-up endoscopies of three patients after one year, one patient after three years and four patients after four years. Conclusions: Acid-reduction and Helicobacter pylori eradication treatment is effective in pyloric stenosis of peptic ulcer disease. Surgery and endoscopic dilation should only be performed in cases of treatment failure.

Özet

Amaç: Benign mide çıkışı tıkanıklığı akut ve kronik peptik ülser hastalığında görülebilmektedir. Cerrahi ve balon dilatasyonu sık uygulanan tedavidir. Bu çalışmada pilor stenozlu hastalarda antiasit ve anti-helikobakter tedavinin etkinliği araştırılmaktadır. Yöntem: 1994-1999 tarihleri arasında pilor stenozu tanısı ile başvuran 12 hasta çalışmaya alınmış,bunlardan 6'sına omeprazol 80mg/gün,ornidazol 1000mg/gün, colloid bizmut 1800 mg/gün 2 hafta verilmiş ve 40 mg omeprazol 4 hafta devam edilmiştir, 4'üne lansoprazol 60 mg/gün, claritromycine 1000 mg/gün, amoxilline 2 gr/gün bir hafta verilmiş ve lansoprazol 60 mg gün 4 hafta devam etmiştir. İki hastaya da lansoprazol 30 mg/gün, claritromycine 1000 mg/gün ve amoxillin 2 gr/gün 1 hafta verilmiş ve lansoprazol 30 mg/gün 6 hafta devam etmiştir. Hastalar tedavi sonrası 4,8 ve 24. haftalarda endoskopi ile izlenmiştir. Bulgular:Tedaviden 4 hafta sonra endoskopik kontrol yapılan biri dışında tüm hastalarda iyileşme gözlenmiştir. Bu hastalarda H.pilori eradike olmuştur. Bir hastada yukarıdaki tedavi ve nazogastrik tedaviye rağmen stenozda düzelme olmamış ve operasyon gerekmiştir. 8. hafta ve 24.haftada endoskopi yapılan 11 hastanın hiçbirinde stenoz veya ülser görülmemiştir. 3 hastaya 1 yıl, 1 hastaya 3 yıl ve 4 hastaya 4 yıl sonra endoskopi yapıldığında nüks görülmemiştir. Sonuç: Peptik pilor obstrüksiyonlu hastalara balon dilatasyonu veya cerrahi tedaviden önce medikal tedavi uygun görülmektedir.

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Cite This Article

YILDIRIM, S., ERDEM, L., KÖKSAL, H. M., BAYKAN, A., MEDE, H. İ., KURT, Ö. (2001). Pilor stenozu tedavisinde asit azaltıcı ve anti-Helicobacter tedavi: Bir prospektif çalışma. Turkish Journal of Gastroenterology, Cilt: 12 - Sayı: 2, 122–125. https://ajindex.com/articles/411237

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