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Journals / Turkish Journal of Gastroenterology / 2001 / Cilt: 12 - Sayı: 1

İltihabi barsak hastalığında factor XIII düzeyinin klinik önemi

Clinical importance of FXIII level in inflammatory bowel disease

Ertuğrul KAYAÇETİN
Ali TÜREYEN
Erkan PARLAK
Selime AYAZ
Aysel ÜLKER
Pages
45–48
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Measurement of FXIII levels is of importance in estimating disease activity and prognosis in inflammatory bowel disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aims: FXIII, the function of which is to preserve hemostasis and repair connective tissue.
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Key Findings & Data:Methods: Serum FXIII levels of 51 patients with ulcerative colitis (28 in active stage and 23 in remission) and 46 patients with Crohn's disease (23 in active and 23 in remission stage) were compared with those of 19 healthy controls.
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Conclusion & Impact:Conclusions: Measurement of FXIII levels is of importance in estimating disease activity and prognosis in inflammatory bowel disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kolit · ülseratif · Crohn hastalığı

Abstract

Background/Aims: FXIII, the function of which is to preserve hemostasis and repair connective tissue. Both congenital and acquired deficiency of FXIII have been described. The aim of this study was to determine whether there is a relationship between FXIII levels detected during the active and remission stage of ulcerative colitis and Crohn's disease and the extent of involvement. Methods: Serum FXIII levels of 51 patients with ulcerative colitis (28 in active stage and 23 in remission) and 46 patients with Crohn's disease (23 in active and 23 in remission stage) were compared with those of 19 healthy controls. Results: FXIII levels were found to be significantly lower in patients with active ulcerative colitis and Crohn's disease compared to those of patients in remission and controls. FXIII levels in those with active ulcerative colitis were significantly lower, on average 85.14, while they were 124.65 in those in remission (p<0.001) and healthy individuals (p<0.001). FXIII levels were also significantly lower in patients with active Crohn's disease (74.82) compared to those in remission (125.8) (p<0.001) and controls (p<0.001). Conclusions: Measurement of FXIII levels is of importance in estimating disease activity and prognosis in inflammatory bowel disease.

Özet

Amaç: FXIII pıhtılaşma zincirinin son komponentidir. Hemostaz ve bağ dokusu tamirinde görevlidir. Bu çalışmanın amacı FXIII düzeylerinin hastalık aktivitesi ve yaygınlığı ile ilişkisini araştırmakdı. Konjenital ve kazanılmış FXIII eksikliği tarif edilmiştir. Yöntem: 28 aktif, 23 'ü remisyonda toplam 51 ülseratif kolit hastası ile, 23'ü aktif 23'ü remisyonda toplam 46 Crohn hastasında ve 19 sağlıklı kontrol olgusunda serum FXIII düzeyleri karşılaştırıldı. Bulgular: Ülse-ratif kolit ve crohn hastalarında aktif dönemdeki FXIII düzeyi, remisyon dönemindeki hastalar ve kontrol olgularındaki FXIII düzeyine göre anlamlı derecede düşük bulundu. Aktif ülseratif kolitli hastalarda ortalama FXIII düzeyi 85.14, remisyondaki ülseratif kolitli hastalarda ise 124.65 idi. Aktif ülseratif kolitlilerde FXIII düzeyi remisyondakilere (p<0.001) ve sağlıklı bireylere göre (p<0.001) anlamlı ölçüde düşük bulunmuştur. Aktif Crohn hastalarında ortalama FXIII düzeyi 125.86 idi. Aktif Crohn hastalarında FXIII düzeyi remisyondakilere (p<0.001) ve kontrol grubuna göre(p<0.001) anlamlı olarak düşük bulunmuştur. Sonuç: İnflamatuar barsak hastalarında, FXIII düzeyi hastalığın aktivitesi ve prognozunu saptamada önemlidir.

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Cite This Article

KAYAÇETİN, E., TÜREYEN, A., PARLAK, E., AYAZ, S., ÜLKER, A. (2001). İltihabi barsak hastalığında factor XIII düzeyinin klinik önemi. Turkish Journal of Gastroenterology, Cilt: 12 - Sayı: 1, 45–48. https://ajindex.com/articles/411224

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