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Journals / Turkish Journal of Gastroenterology / 2003 / Cilt: 14 - Sayı: 4

İnflamatuvar barsak hastalığı olan kadınlarda menstrüel siklus dönemlerinde gastrointestinal ve psikosomatik semptomlar

Pattern of gastrointestinal and psychosomatic symptoms across the menstrual cycle in women with inflammatory bowel disease

Erkan PARLAK
Ülkü DAĞLI
CANAN ALKIM
SELÇUK DİŞİBEYAZ
Bilge TUNÇ
Aysel ÜLKER
Burhan ŞAHİN
Pages
250–256
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Disease activity and the drug used may modify the severity of the symptoms.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aims: The purpose of this study was to determine the frequency of defecation, gastrointestinal (GI) and non-GI symptoms among women with ulcerative colitis (UC) (n=38) and Crohn's disease (CD) (n=21), and to compare the results with those from healthy women (n=38) across the menstrual cycle.
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Key Findings & Data:These decreased in the postmenstrual phase in controls, and in patients with UC and remitting CD.
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Conclusion & Impact:Disease activity and the drug used may modify the severity of the symptoms.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Crohn hastalığı · Kolit · ülseratif

Abstract

Background/aims: The purpose of this study was to determine the frequency of defecation, gastrointestinal (GI) and non-GI symptoms among women with ulcerative colitis (UC) (n=38) and Crohn's disease (CD) (n=21), and to compare the results with those from healthy women (n=38) across the menstrual cycle. Methods: Women were followed for three menstrual cycles with a symptom diary consisting of frequency of defecation, and GI and non-GI symptoms. One point was allowed for each symptom in the same phases of three cycles, and total scores for GI and non-GI symptoms were obtained. Results: Frequency of defecation was found to be higher during menstruation in controls and in remitting UC and CD. GI symptom scores were higher in all three phases in patients with CD. These decreased in the postmenstrual phase in controls, and in patients with UC and remitting CD. In all three cycles, non-GI symptom scores were higher in patients with CD. These symptoms decreased during the postmenstrual period in all three groups. Th e activation of UC and CD did not affect the non-GI symptom score in the same menstrual cycle. Patients on mesalamine had less GI and non-GI complaints than those on sulfasalazine in all phases. There was no correlation between GI and non-GI symptom scores during all menstrual phases. Conclusion: Cyclic pattern present in healthy women persisted in patients with UC and CD. Disease activity and the drug used may modify the severity of the symptoms.

Özet

Amaç: Bu çalışmanın amacı ülseratif kolit (ÜK) (n=38) ve Crohn Hastalığı (CH) olan (n=21) kadınlarda menstrüel siklus boyunca defekasyon sıklığını, gastrointestinal (GI) ve non-GI semptomları tesbit etmek ve sağlıklı kadınlarla (n=38) karşılaştırmaktır. Yöntem: Çalışmaya katılan kadınlar 3 menstrüel siklus boyunca defekasyon sıklığı, GI ve non-GI semptomları içeren semptom günlüğünü doldurdular. Her fazda herbir semptoma 1 puan verildi ve o faz için ortalama skorlar elde edildi. Bulgular: Defekasyon sıklığı kontrol grubu ile ÜK ve CH olan hastalarda menstürasyon sırasında daha fazla idi. CH olan hastalarda her üç fazda GI semptom skorları daha yüksekti. GI skorlar kontrollerde, ÜK'de ve remisyonda CH'nda postmenstrüel fazda azalıyordu. Her üç siklusta non-GI semptom skorları CH olan hastalarda daha yüksekti. Non GI semptom skorları her üç grupta da postmenstrüel periyodda azalıyordu. ÜK ve CH aktivasyonu GI semptom skorlarını etkilemiyordu. Mesalamin kullanan hastalarda GI ve non-GI semptomlar tüm fazlarda sülfazalazin alanlardan daha azdı. GI ve non-GI skorlar arasında menstrüel siklusun hiçbir fazında korelasyon yoktu. Sonuç: ÜK ve CH olan kadınlarda sağlıklı kadınlarda mevcut siklik pattern korunmaktadır. Hastalık aktivitesi ve kullanılan ilaçlar semptomların şiddetini değiştirebilir.

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Cite This Article

PARLAK, E., DAĞLI, Ü., ALKIM, C., DİŞİBEYAZ, S., TUNÇ, B., ÜLKER, A., ŞAHİN, B. (2003). İnflamatuvar barsak hastalığı olan kadınlarda menstrüel siklus dönemlerinde gastrointestinal ve psikosomatik semptomlar. Turkish Journal of Gastroenterology, Cilt: 14 - Sayı: 4, 250–256. https://ajindex.com/articles/411209

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