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Journals / Turkish Journal of Gastroenterology / 2004 / Cilt: 15 - Sayı: 2

Kronik hepatit B’de alfa interferon kullanımına bağlı gelişen aksonal nöropati ve işitme kaybı: Olgu sunumu

Axonal neuropathy and hearing loss associated with alpha interferon treatment in chronic hepatitis B: A case report

Ayşe TUNCA
Mustafa ERBAYRAK
Şirin AYTAÇ
Cansel TÜRKAY
Pages
97–99
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, the development of polyneuropathy and sensorineural hearing loss in the same patient may suggest autoimmunity as the cause of these side effects.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The effect of interferon alpha in chronic viral hepatitis and common side effects are well known, but axonal polyneuropathy and hearing loss have been rarely reported.
📊
Key Findings & Data:A 58-year-old woman was administered interferon alpha-2a (9 MU/3 times a week) and lamividin (100 mg daily) with the diagnosis of chronic hepatitis B.
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Conclusion & Impact:In conclusion, the development of polyneuropathy and sensorineural hearing loss in the same patient may suggest autoimmunity as the cause of these side effects.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İşitme kaybı · sensorinöral · İnterferon-alfa

Abstract

The effect of interferon alpha in chronic viral hepatitis and common side effects are well known, but axonal polyneuropathy and hearing loss have been rarely reported. A 58-year-old woman was administered interferon alpha-2a (9 MU/3 times a week) and lamividin (100 mg daily) with the diagnosis of chronic hepatitis B. At the fifth month of the treatment gait disturbance and tinnitus developed. In her neurological examination tandem gait was ataxic on the right side. Cerebral magnetic resonance imaging performed to elucidate a probable cerebral pathology revealed nonspecific millimetric hyperintense lesions thought to be related with her hypertension anamnesis. Electroneuromyography demonstrated mild axonal polyneuropathy. The finding of pure-tone audiometry was sensorineural hearing loss in her left ear. Our diagnosis was axonal polyneuropathy and sensorineural type hearing loss as a side effect of interferon. In conclusion, the development of polyneuropathy and sensorineural hearing loss in the same patient may suggest autoimmunity as the cause of these side effects.

Özet

Kronik viral hepatitlerin tedavisinde etkinliği kanıtlanmış olup, yaygın olarak kullanılan Alfa interferona bağlı aksonal nöropati ve işitme kaybı ender rastlanan yan etkilerdendir. 58 yaşında bayan hasta, kronik hepatit B tanısı ile interferon alfa-2a; haftada 3 gün 9 MÜ ve lamividin 100mg/gün başlandı. Tedavinin 5. ayında dengesizlik, kulak uğultusu şikayeti ile başvuran hastanın nörolojik muayenesi tandem yürüyüş sağa ataksik dışında normal idi. Serebral patalojiyi ekarte etmek için yapılan Beyin Mağnetik Resonans Görüntülemede; milimetrik nonspesifik hiperintens odaklar görüldü. Bu bulgu öyküdeki hipertansiyon ile uyumlu olarak düşünüldü. Elektronöromyogram bulguları hafif aksonal polinöropati ile uyumlu idi. Odyometride sol kulakta sensorinöral tip işitme kaybı mevcuttu. Hastada alfa interferona bağlı aksonal polinöropati ve sensorinöral işitme kaybı düşünüldü. Sonuçta, ayni hastada hem polinöropati, hem de sensorinöral işitme kaybının beraber olması etyolojide otoimmünitenin yer aldığını düşündürebilir.

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Cite This Article

TUNCA, A., ERBAYRAK, M., AYTAÇ, Ş., TÜRKAY, C. (2004). Kronik hepatit B’de alfa interferon kullanımına bağlı gelişen aksonal nöropati ve işitme kaybı: Olgu sunumu. Turkish Journal of Gastroenterology, Cilt: 15 - Sayı: 2, 97–99. https://ajindex.com/articles/411205

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