Asid reflü akciğer hastalığına neden olur mu?

Key Findings & Data:Standardized methods of esophageal manometry and ambulatory 24-h esophageal pH testing were used throughout the study period, along with a standardized reşux and respiratory symptom questionnaire.

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Conclusion & Impact:Better-designed prospective cohort studies may provide further insight.

🔬Design:Survey & Empirical Study

📍Scope:Comprehensive Sample

⚙️Variables:Gastroözefageal reflü · Tanı teknikleri · sindirim sistemi

Abstract

Background/aims: Gastroesophageal reşux is considered as a factor in pulmonary diseases. The aim of this study was to assess whether gastroesophageal reşux is associated with abnormalities in lung function in patients without respiratory disease. Methods: Forty- four patients with reşux symptoms were studied prospectively. Standardized methods of esophageal manometry and ambulatory 24-h esophageal pH testing were used throughout the study period, along with a standardized reşux and respiratory symptom questionnaire. Spirometric measurements were performed in all patients. Results: Reşux to distal esophagus was observed in 9 patients, to proximal esophagus in 4 and to both distal and proximal in 20 of the 44 patients. Eleven patients revealed reşux neither to distal nor proximal esophagus. Respiratory function tests of these groups showed no significant differences (p>0.05). Conclusion: There is no correlation between esophageal acid events and respiratory function tests. There are no data to answer the question of whether or not reşux precedes onset of cough/asthma. Better-designed prospective cohort studies may provide further insight.

Özet

Amaç: Gastroesophageal reşu, akciğer hastalıklarının oluşumunda sorumlu faktörlerden biri olarak düşünülmektedir. Bu çalışmanın amacı; solunum yolu hastalığı olmayan olgularda gastroözofageal reflünün solunum fonksiyon bozukluğu ile ilişkisi olup olmadığını araştırmaktır. Yöntem: Reflü semptomları olan 44 olgu prospektif olarak çalışmaya alınmıştır. Olguların tümüne özofagus manometrisi, 24 saatlik pH monitorizasyonu ve spirometri yapılmıştır. Bulgular: Distal özofagusa patolojik reflü 9 olguda, proksimal özofagusa reflü 4 olguda, hem distal hem proksimale reflü 20 olguda tespit edilmiştir. On bir olguda ne distale ne proksimale patolojik reflü izlenmemiştir. Bu gruplar arasında solunum fonksiyon testleri açısından anlamlı farklılık gözlenmemiştir (p>0.05). Sonuç: Özofagusa asid reflüsü ile solunum fonksiyon testleri arasında anlamlı bir ilişki bulunmamıştır. Asit rflşünün astımı başlatıp başlatmadığına dair yeterli veri yoktur. Bu konuda yapılacak daha ileri çalışmalara gereksinim vardır.

Keywords

Gastroözefageal reflü Tanı teknikleri sindirim sistemi İleriye dönük çalışma Solunum fonksiyon testleri Özofagal pH izlemesi Gastroesophageal Reflux Diagnostic Techniques Digestive System Prospective Studies Respiratory Function Tests Esophageal pH Monitoring

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Cite This Article

ATALAY, F., DAĞLI, Ü., KURAN, S., ÖZİN, Y., ERNAM, D., ŞAHİN, B. (2005). Asid reflü akciğer hastalığına neden olur mu?. Turkish Journal of Gastroenterology, Cilt: 16 - Sayı: 4, 199–202. https://ajindex.com/articles/411186

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References (12)

Cohen S, Parkmen HP. Diseases of the esophagus. In: Cecil RL, Goldman L, Bennett JC, eds. Cecil Textbook of Medicine. 21st ed. Philadelphia, PA: W.B. Saunders, 2000; 658-68
Harding, SM. Nocturnal asthma: role of nocturnal gastroesophageal reflux. Chronobiol Int 1999; 16: 641-62
De Meester TR, Wang CI, Wernly CA, et al. Technique, indications and clinical use of 24-hour esophageal pH monitoring. J Thorac Cardiovasc Surg 1980; 79: 656-67
Smit CF, Tan J, Devriese PP, et al. Ambulatory pH monitoring at the upper esophageal sphincter. Laryngoscope 1998; 108: 299-302
Richter JE. Typical and atypical presentations of gastroesophageal reflux disease. The role of esophageal testing in diagnosis and management. Gastroenterol Clin North Am 1996; 25: 75-102
Cool M, Poelmans J, Feenstra L, et al. Characteristics and clinical relevance of proximal esophageal pH monitoring. Am J Gastroenterol 2004; 99: 2317-23
Locke GR III, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 1997; 112: 1448-56. 8. el-Serag HB, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology 1997; 113: 755-60
Irwin RS, Curley FJ, French CL. Chronic cough: the spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis 1990; 141: 640-7
Field SK, Underwood M, Brant R, et al. Prevalence of gastroesophageal reflux symptoms in asthma. Chest 1996; 109: 316-22
Harding SM, Sontag SJ. Asthma and gastroesophageal reflux. Am J Gastroenterol 2000; 95 (Suppl 8): S23-S32
Sifrim D, Silny J, Holloway RH, et al. Patterns of gas and liquid reflux during transient lower esophageal sphincter relaxation: a study using intraluminal electrical impedance. Gut 1999; 44: 47-54
Zentilin P, Dulbecco P, Savarino E, et al. Combined multichannel intraluminal impedance and pH-metry: a novel technique to improve detection of gastro-oesophageal reflux. Literature review. Dig and Liver Dis 2004; 36: 565-9.