Mantle hücreli lenfomanın diffüz gastrointestinal tutulumu

Key Findings & Data:Multiple lymphomatous polyposis is characterized by multiple polypoid lesions involving long segments of the gastrointestinal tract and it accounts for 2% of primary gastrointestinal tract lymphomas.

💡

Conclusion & Impact:The patient was successfully treated by combination chemotherapy.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Kontrast ortamı · Yaşlı · Baryum

Abstract

The gastrointestinal tract is the predominant site of appearance of extranodal non-Hodgkin lymphomas. The most frequent endoscopic finding of mantle cell lymphoma is multiple lymphomatous polyposis, which is a very rare entity. Multiple lymphomatous polyposis is characterized by multiple polypoid lesions involving long segments of the gastrointestinal tract and it accounts for 2% of primary gastrointestinal tract lymphomas. A 68-year-old patient was admitted to our clinic with intermittent diarrhea, weight loss, hematochezia and fatigue. Multiple lymphomatous polyposis was detected on the endoscopic evaluations. Gastrointestinal mantle cell lymphoma was confirmed with histopathological and immunohistochemical studies on biopsy specimens from colon, small intestine and stomach. The patient was successfully treated by combination chemotherapy.

Özet

Gastrointestinal sistem ekstranodal non Hodgkin lenfomaların en sık görüldüğü yerdir. Mantle hücreli lenfomanın en sık endoskopik bulgusu multipl lenfomatöz polipozistir. Multipl lenfomatöz polipozis oldukça nadir bir durumdur. Multipl lenfomatöz polipozis gastrointestinal sistem segmentlerini tutan multipl polipoid lezyonlarla karakterizedir ve primer gastrointestinal lenfomaların %2’sini oluşturmaktadır. 68 yaşındaki hasta aralıklı diare, hematokezya ve güçsüzlükle kliniğimize başvurdu. Endoskopik değerlendirmede multipl lenfomatöz polipozis görüldü. Kolon, ince barsak ve mide biyopsi örneklerinin histopatolojik ve immunohistokimyasal değerlendirmesinde mantle hücreli lenfoma tanısı doğrulandı. Hasta kombinasyon tedavisi ile başarılı şekilde tedavi edildi.

Keywords

Kontrast ortamı Yaşlı Baryum Biyopsi Bağırsak neoplazmları Bağırsak ince Mide neoplazmları Tomografi x-ışınlı bilgisayarlı Bağırsak polipleri Antineoplastik birleşik kemoterapi protokolleri Siklofosfamid Doksorubisin Prednizolon Vinkristin Endoskopi sindirim sistemi Lenfoma Mantle hücreli Kolon Contrast Media Aged Barium Biopsy Intestinal Neoplasms Intestine Small Stomach Neoplasms Tomography X-Ray Computed Intestinal Polyposis Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Prednisolone Vincristine Endoscopy Digestive System Lymphoma Mantle-Cell Colon

🔖

Cite This Article

MERAL, M., DEMİRPENÇE, M., GÖNEN, C., AKARSU, M., KAYAHAN, H., DEMİRKAN, F., KARGI, A., AKPINAR, H. (2008). Mantle hücreli lenfomanın diffüz gastrointestinal tutulumu. Turkish Journal of Gastroenterology, Cilt: 19 - Sayı: 2, 117–120. https://ajindex.com/articles/411176

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (10)

Tamura S, Ohkawauchi K, Yokoyama Y, et al. Non-multiple lymphomatous polyposis form of mantle cell lymphoma in the gastrointestinal tract. J Gastroenterol 2004; 39: 995- 1000
Weisenburger DD, Armitage JO. Mantle cell lymphoma -- an entity comes of age. Blood 1996; 87: 4483-94
Amer MH, el-Akkad S. Gastrointestinal lymphoma in adults: clinical features and management of 300 cases. Gastroenterology 1994; 106: 846-58
Tamura S, Ohkawauchi K, Yokoyama Y, et al. Multiple lymphomatous polyposis form is common but not specific for mantle cell lymphoma in the gastrointestinal tract. (Editorial). J Gastroenterol 2004; 39: 1023-4
Hashimoto Y, Nakamura N, Kuze T, et al. Multiple lymphomatous polyposis of the gastrointestinal tract is a heterogenous group that includes mantle cell lymphoma and follicular lymphoma: analysis of somatic mutation of immunoglobulin heavy chain gene variable region. Hum Pathol 1999; 30: 581-7
Cornes JS. Multiple lymphomatous polyposis of the gastrointestinal tract. Cancer 1961; 14: 249-57
Ruskone-Fourmestraux A, Delmer A, Lavergne A, et al. Multiple lymphomatous polyposis of the gastrointestinal tract: prospective clinicopathologic study of 31 cases. Groupe D'etude des Lymphomes Digestifs. Gastroenterology 1997; 112: 7-16
Remes-Troche JM, De-Anda J, Ochoa V, et al. A rare case of multiple lymphomatous polyposis with widespread involvement of the gastrointestinal tract. Arch Pathol Lab Med 2003; 127: 1028-30
Campo E, Raffeld M, Jaffe ES. Mantle-cell lymphoma. Semin Hematol. 1999; 36: 115-27
Tamura S, Ohkawauchi K, Yokoyama Y, et al. Non-multiple lymphomatous polyposis form of mantle cell lymphoma in the gastrointestinal tract. J Gastroenterol 2004; 39: 995- 1000.