Journals / Turkish Journal of Gastroenterology / 2007 / Cilt: 18 - Sayı: 4

Tip 2 diabetes mellitus ve Helikobakter pilori ilişkisi

Association between type 2 diabetes mellitus and Helicobacter pylori infection

Pages
225–229
DOI
—
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AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Helicobacter pylori infection was significantly higher in diabetic obese patients than non-diabetic subjects.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aims: It is well known that patients with diabetes mellitus are more prone to infection.
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Key Findings & Data:The aim of this study was to determine the association between Helicobacter pylori infection and type 2 diabetes mellitus in the United Arab Emirates population.
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Conclusion & Impact:Helicobacter pylori infection was significantly higher in diabetic obese patients than non-diabetic subjects.
🔬Design:Research Article
📍Scope:2002 Verileri
⚙️Variables:Diabetes mellitus · tip 2 · Helicobacter pylori

Abstract

Background/aims: It is well known that patients with diabetes mellitus are more prone to infection. In patients with diabetes mellitus, chronic infections are frequent and severe, due to the impairment of their immune status. The aim of this study was to determine the association between Helicobacter pylori infection and type 2 diabetes mellitus in the United Arab Emirates population. This is a case and control study comparison of type 2 diabetes mellitus and non-diabetic groups. The study was conducted at the primary health care clinics in United Arab Emirates during the period from June 2002 to August 2003. The study included 210 type 2 diabetes mellitus patients and 210 non-diabetic subjects. Methods: Helicobacter pylori was assessed by histopathological examination by measuring antibody profiles (IgG and IgA) among type 2 diabetes mellitus patients and the non-diabetic group. Results: The mean age of type 2 diabetes mellitus patients infected with Helicobacter pylori was 48.1 ± 7.9 years compared to 46.7 ± 5.4 years in the non-diabetic infected subjects. A positive antibody titer for Helicobacter pylori infection (IgA &#8805;300) was found in 76.7% of the diabetic subjects compared to 64.8% of the non-diabetic subjects (p<0.009). There was higher prevalence of Helicobacter pylori infection in diabetic obese patients than the non-diabetic subjects (23.6% vs 11.8%, p<0.001). Muscular (47.2%), gastrointestinal (29.8%), chronic bronchitis (22.4%), nausea (19.9%), anemia (18%), abdominal pain (12.4%), diarrhea (10.6%) and vomiting (7.5%) were more common in diabetic patients infected with Helicobacter pylori. Conclusions: The present study suggests that there is a significant association between Helicobacter pylori infection and type 2 diabetes mellitus. Helicobacter pylori infection was significantly higher in diabetic obese patients than non-diabetic subjects.

Özet

Amaç: Diabetes mellitus'lu hastaların enfeksiyona yatkınlığı bilinen bir husustur. Diabetes mellituslu hastalarda, immün sistemin yetersizliğinden dolayı kronik enfeksiyon daha sık ve şiddetlidir. Bu çalışmanın amacı, Birleşik Arap Emirlikleri halkında, Helikobakter pilori enfeksiyonu ve tip 2 diabetes mellitus arasında olası ilişkinin araştırılmasıdır. Bu çalışma tip 2 diabetes mellitus ve non-diabetik grupların karşılaştırıldığı bir vaka-kontrol çalışmasıdır. Çalışma Birleşik Arap Emirlikleri'nde birinci basamak ünitelerinde Haziran 2002- Ağustos 2003 arasında yapıldı. Çalışmaya 210 tip 2 diabetes mellitus ve 210 non-diabetik hasta dahil edildi. Metodlar: Helikobakter pilori hastalarda histopatolojik örneklerde IgG ve IgA antikorları bakılarak araştırıldı. Bulgular: Helikobakter pilori ile enfekte tip 2 diabetes mellitus'luların ortalama yaşı 48.1 ± 7.9, non-diabetik kontrol grubunun ise 46. 7 ± 5.4 idi. Helikobakter pilori enfeksiyonu için pozitif antikor titresi (IgA≥300) diabetik hastaların %76.7'sinde, kontrol grubunun ise %64.8'inde görüldü (p<0.009). Diabetik obez hastalarda non-diabetik kontrollere göre daha yüksek Helikobakter pilori prevalansı mevcuttu (23.8% vs. 11.8%, p<0.001). Müsküler (%47.2), gastrointestinal (%29.8), kronik bronşit (%22.4), bulantı (%19.9), anemi (%18), karın ağrısı (%12.4) ve kusma (%7.5) Helikobakter pilori ile enfekte diabetik hastalarda daha sıktı. Sonuç: Bu çalışma Helikobakter pilori enfeksiyonu ile tip 2 diabetes mellitus arasında anlamlı bir ilişki olduğunu düşündürmektedir. Helikobakter pilori enfeksiyonu, diabetik obez hastalarda non-diabetik kişilere göre anlamlı olarak daha fazla saptanmıştır.

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Cite This Article

BENER, A., MICALLEF, R., AFIFI, M., DERBALA, M., AL-MULLA, H. M., USMANI, M. A. (2007). Tip 2 diabetes mellitus ve Helikobakter pilori ilişkisi. Turkish Journal of Gastroenterology, Cilt: 18 - Sayı: 4, 225–229. https://ajindex.com/articles/411167

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