Journals / Turkish Journal of Gastroenterology / 2013 / Cilt: 24 - Sayı: 6

Alkol suistimali olan iki hastada görülen ikterohemorajik leptosiroz

Icterohaemorrhagic leptospirosis in patients with history of alcohol abuse report of two cases

Pages
549–555
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

One of the cases was with lethal outcome.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Leptospirosis is a re-emerging zoonosis caused by spirochetes from the genus Leptospira and is typically associated with rural settings.
📊
Key Findings & Data:Transmission occurs via contact with urine from infected animals; incubation period ranges from 4 days to 4 weeks.
💡
Conclusion & Impact:One of the cases was with lethal outcome.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Leptospirosis is a re-emerging zoonosis caused by spirochetes from the genus Leptospira and is typically associated with rural settings. Transmission occurs via contact with urine from infected animals; incubation period ranges from 4 days to 4 weeks. The clinical spectrum of leptospirosis may be mild and self-limited or severe with jaundice, renal failure, and bleeding manifestations (icterohaemorrhagic leptospirosis, so called Weil s disease). Mortality in severe forms remains high even when optimal treatment is provided. Early clinical suspicion and laboratory confirmation of leptospirosis is essential since delays in diagnosis may increase mortality. Alcohol-related toxicity and alcoholic hepatitis are common pathological processes, which can occasionally produce clinical syndromes similar to leptospirosis. There are few reports regarding the clinical course of leptospirosis in chronic alcoholics. Here, we describe two patients with Weil s disease, in whom alcohol abuse caused therapeutic difficulties. One of the cases was with lethal outcome.

Özet

Leptospiroz, spiroketlerin neden oldu¤u genellikle kırsal yaşamla ilifşkili olan ve son dönemde sıklığında artış görülen zoonoz bir enfeksiyondur. Bulaş, enfekte hayavanların idrarına temas ile olur, inkübasyon süresi 4 gün ile 4 hafta arasındadır. Klinik tablo kendini sınırlayan hafif leptospirozdan, sarılık, böbrek yetmezliği ve kanama ile karakterize ikterohemorajik leptospiroz, Weil hastalığına kadar değişebilir. Optimal tedaviye rağman ağır seyreden formlarında mortalite yüksektir. Tanı için erken klinik şüphe ve labaratuvar ile doğrulama gereklidir ve tanının gecikmesi halinde mortalite artar. Alkole bağlı toksisite ve alkolik hepatit sık görülen sorunlardır ve nadiren leptospiroz benzeri tabloya neden olabilirler. Kronik alkoliklerde leptospirozun klinik seyri hakkında az sayıda yayın bulunmaktadır. Burada, alkol kullanımı nedeni ile tedavide güçlük çekilen iki Weil hastası sunulmuştur. Hastalardan birinde seyrin sonunda ölüm gerçekleşmiştir.

🔖

Cite This Article

GANCHEVA, G., KARCHEVA, M. (2013). Alkol suistimali olan iki hastada görülen ikterohemorajik leptosiroz. Turkish Journal of Gastroenterology, Cilt: 24 - Sayı: 6, 549–555. https://ajindex.com/articles/411093

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Levett PN. Leptospirosis. Clin Microbiol Rev 2001; 14:296- 326
  2. McBride AJ, Athanazio DA, Reis MG, et al. Leptospirosis. Curr Opin Infect Dis 2005; 18:376-86
  3. Kobayashi Y. Human leptospirosis: management and prog- nosis. J Postgrad Med 2005; 51:201-4
  4. Gao B. Interaction of alcohol and hepatitis viral proteins: implication in synergistic effect of alcohol drinking and vi- ral hepatitis on liver injury. Alcohol 2002; 27:69-72
  5. Meyer RA, Duffy MC. Spontaneous reactivation of chronic hepatitis B infection leading to fulminant hepatic failure. Report of two cases and review of the literature. J Clin Gas- troenterol 1993; 17: 231-4
  6. O’Beirne J, Patch D, Holt S, et al. Alcoholic hepatitis-the case for intensive management. Postgrad Med J 2000; 76:504-7
  7. Leonidas C, Kalambokis G, Tsianos EV. Weil’s Disease in a Patient with Chronic Viral Hepatitis and History of Alcohol Abuse. Inter Med 2008; 47:933-7
  8. Kaushik SP, Yim HB, Tan CC. Weil’s syndrome and conco- mitant hepatitis B infection. Singapore Med J 1999; 40:104-5
  9. Gerke P, Rump LC. Leptospirosis-3 cases and a review. Clin Nephrol 2003; 60:42-8
  10. Sitprija V, Losuwanrak K, Kanjanabuch T. Leptospiral nephropathy. Semin Nephrol 2003; 23:42-8
  11. Mathew T, Satishchandra P, Mahadevan A, et al. Neuro- leptospirosis-revisited: experience from a tertiary care ne- urological centre from south India. Indian J Med Res 2006; 124:155-62
  12. Wang SC, Wang YM. Leptospirosis: report of one case. J Microbiol Immunol Infect 1999; 32:129-32
  13. Bal AM. Unusual clinical manifestations of leptospirosis. J Postgrad Med 2005; 51:179-83
  14. Watson RR, Borgs P, Witte M, et al. Alcohol, immunomo- dulation, and disease. Alcohol Alcohol 1994; 29:131-9
  15. Katz AR, Ansdell VE, Effler PV, et al. Assessment of the clinical presentation and treatment of 353 cases of labora- tory confirmed leptospirosis in Hawaii, 1974-1998. Clin In- fect Dis 2001; 33:1834-41
  16. Griffith ME, Hospenthal DR, Murray CK. Antimicrobial therapy of leptospirosis. Curr Opin Infect Dis 2006; 19:533- 7.