AI Summary & Key Takeaways
AI InsightIn conclusion, the findings of this study suggest that the aneuploidy peak of cardia cancer is higher than antrum cancer and that the aneuploidy peak of undifferentiated cancer is greater than adenocarcinoma.
📌 3 Key Takeaways
Abstract
Flowcytometric analysis has started to be used to determine the biological behaviour of tumors (Tm). This study evaluated the relationship between the location and histopathologic and flowcytometric analysis of gastric cancer. Biopsies of 44 patients with gastric cancer were examined by histopathologic and flowcytometric analysis, evaluation of which showed: nine patients with cardia Tm (mean age: 61.7±9.8), 10 patients with corpus Tm (mean age: 59±11.1), 24 patients with antrum Tm (mean age: 59±11.1) and one patient with linitis plastica (age 67 years). The DNA ploidy indexes of the cardia, corpus and antrum cancer and linitis plastica biopsies of patients were found to be 1.33±0.24, 1.72±0.17, 1.19±0.18, 1.180 respectively. The aneuploidy peak of cardia tumor was higher than the antrum tumor (p<0.05), but there was no significant difference between the cardia and the corpus tumor. Also there was no difference between the aneuploidy peak values of the corpus and antrum tumors. Histopathologically, 29 patients( 66%) had adenocarcinoma and 15 (34%) patients had undifferentiated cancer. The DNA ploidy index of the undifferentiated cancer group of 1.307±0.16 was higher than the adenocarcinoma gropup of 1.162±0.18 (p<0.007). In conclusion, the findings of this study suggest that the aneuploidy peak of cardia cancer is higher than antrum cancer and that the aneuploidy peak of undifferentiated cancer is greater than adenocarcinoma.
Özet
Akımsitometrik analiz son yıllarda bir çok tümörün biyolojik davranışını değerlendirmede kullanılmaktadır. Bu çalışmada mide kanserinin lokalizasyonu ve histopatolojik tipi ile DNA ploidi indeksi arasındaki ilişki araştırıldı. Çalışmaya 44 hasta kabul edildi. Üst gastrointestinal sistem endoskopisi ile tanımlanan lezyonlardan biopsiler alındı. Örnekler histopatolojik ve akımsitometrik analizle değerlendirildi. Dokuz hasta kardiya kanseri (yaş ortalaması: 61.7±9.8), 10 hasta korpus kanseri (yaş ortalaması: 61.5±9.54), 24 hasta antrum kanseri (yaş ortalaması: 59±11.1), 1 hasta linitis plastika (yaş 67) idi. DNA ploidi indeksi; kardiya kanseri: 1.33±0.24, korpus kanseri: 1.22±0.17, antrum kanseri: 1.19± 0.18, linitis plastika: 1.180 idi. Kardiya kanserinin aneuploidi piki antrum kanserinden fazla iken (p<0.05), korpus kan-serinden farklılık göstermedi. Korpus ve antrum kanseri farklılık göstermedi. Yirmidokuz (%66) hasta adenokanser, 15 (%34) hasta indiferansiye kanserdi. İndiferansiye kanserde DNA ploidi indeksi 1.307±0.16 idi, ve adenokanserden 1.162±0.18 yüksekti (p<0.007). Bu çalışmada kardiya kanserinde aneuploidi pikinin antrum kanserinden, indiferansiye kanserde adenokanserden fazla olduğu gözlemlenmiştir.