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Journals / Turkish Journal of Gastroenterology / 2003 / Cilt: 14 - Sayı: 1

Vitamin B12 eksikliğinin prediktörleri: Yaş ve antral mukozanın Helicobacter pylori yükü

Predictors of vitamin B12 deficiency: Age and Helicobacter pylori load of antral mucosa

YÜKSEL GÜMÜRDÜLÜ
ENDER SERİN
BİROL ÖZER
FAZİLET KAYASELÇUK
Kemal KUL
Cengiz PATA
Mustafa GÜÇLÜ
Gürden GÜR
Sedat BOYACIOĞLU
Pages
44–49
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Hematologic parameters are not useful in predicting the deficiency of this vitamin.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aims: The aim of this study was to assess the fre-quency of vitamin B12 deficiency in patients with non atrophic gastric mucosa and any relationship between the presence of vitamin B12 deficiency and demographic, hematologic, and histopathotogic parameters.
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Key Findings & Data:Variables that might influence or predict the presence of vitamin B12 deficiency (age, gender, hemoglobin, mean corpuscular volume, serum folate level, scores of histologic parameters) were evaluated by univariate/ multivariate analysis.
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Conclusion & Impact:Hematologic parameters are not useful in predicting the deficiency of this vitamin.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Vitamin B12 eksikliği · Helicobacter pylori · Yaş faktörü

Abstract

Background/aims: The aim of this study was to assess the fre-quency of vitamin B12 deficiency in patients with non atrophic gastric mucosa and any relationship between the presence of vitamin B12 deficiency and demographic, hematologic, and histopathotogic parameters. Methods: Three hundred and ten patients with no gastric mucosal atrophy on histologic evaluation were included in the study. Chronic inflammation, neutrophil activity and H. pylori load were scored using the Sydney classification system. Variables that might influence or predict the presence of vitamin B12 deficiency (age, gender, hemoglobin, mean corpuscular volume, serum folate level, scores of histologic parameters) were evaluated by univariate/ multivariate analysis. Results: The percentages of patients with vitamin B12 concentrations of < 250 pg/mL, < 200 pg/mL, and <100 pg/mL were 67.4%, 46.8% and 6.5% respectively. Patient age and all three histologic were inversely related to vitamin B12 deficiency (p<0.05). By multivariate analysis, factors independently associated with serum vitamin B12 deficiency were age and antral H. pylori load (p<0.05). Conclusions: The higher frequency of vitamin B12 deficiency in this study compared with a western study maybe a reflection of the effect of H. pylori infection on serum vitamin B12 level. In addition, age was shown to be an independent risk factor for vitamin B12 deficiency irrespective of gastric atrophy. It is already known that the presence of H. pylori on gastric mucosa influence serum vitamin B12 levels. Hematologic parameters are not useful in predicting the deficiency of this vitamin.

Özet

Amaç: Non atrofik gastrik mukozası olanlar hastalarda vitamin B 12 eksikliğinin sıklığını ve vitamin B 12 eksikliği ile demografik, hematolojik ve histolojik parametrelerin ilişkisini değerlendirmeyi amaçladık. Yöntem: Histolojik değerlendirmede gastrik mükozal atrofisi olmayan 310 hasta çalışmaya dahil edildi. Kronik inflamasyon, nötrofil aktivasyonu ve H. pylori yükü Sydney sınıflaması kullanılarak skorlandı. vitamin B 12 eksikliğini etkileyebilecek veya predikte edebilecek yaş, cinsiyet, hemoglobin, MCV, serum folat seviyesi ve histolojik parametrelerin skoru gibi değişiklikler univaryant / multivaryant analizlerle değerlendirildi. Bulgular: Hastaların %67,4'ünde vitamin B12< 250 pglmL, 46.8%'inde < 200 pg/mL ve 6.5%'inde <100pg/mL idi. Hastaların yaşı ve histolojik özelliklerin tümü ile vitamin B 73 eksikliği arasında negatif korelasyon vardı (p<0.05). Multivaryant analizde yaş ve antral H. pylori yükü vitamin B12 eksikliği ile bağımsız olarak ilişkiliydi (p<0.05). Sonuç: Batıda yapılan çalışmaya göre yüksek sıklıkta vitamin B12 eksikliğinin olması H. pylori enfeksiyonunun serum vitamin B12 enfeksiyonuna etkisini yansıtıyor olabilir. Bu gastrik mükozal atrofi bulunmayan hasta grubu, yaşın gastrik atrofi ile ilişkisiz olarak vitamin B12 eksikliğinin bağımsız risk faktörü olduğunu ve her halükarda gastrik mukozada H. pylori bulunmasının vitamin B12 seviyesini etkilediğini göstermiştir. Bu vitaminin eksikliğini predikte etmekte hematolojik parametreler kullanışlı değildir.

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Cite This Article

GÜMÜRDÜLÜ, Y., SERİN, E., ÖZER, B., KAYASELÇUK, F., KUL, K., PATA, C., GÜÇLÜ, M., GÜR, G., BOYACIOĞLU, S. (2003). Vitamin B12 eksikliğinin prediktörleri: Yaş ve antral mukozanın Helicobacter pylori yükü. Turkish Journal of Gastroenterology, Cilt: 14 - Sayı: 1, 44–49. https://ajindex.com/articles/410913

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