Journals / Turkish Journal of Gastroenterology / 2011 / Cilt: 22 - Sayı: 1

Oral bal ve polenin postoperatif intraabdominal adezyonlar üzerine etkisi

The effect of oral honey and pollen on postoperative intraabdominal adhesions

Pages
65–72
DOI
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Conclusions: Honey and pollen were found to be effective in preventing postoperative intraabdominal adhesions, and these effects were thought to be a result of their antiinflammatory and antioxidant properties.

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Objective & Hypothesis:Background/aims: We evaluated the effect of oral usage of honey and pollen, either separately or together, on postoperative intraabdominal adhesions.
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Key Findings & Data:Methods: Forty rats were randomly separated into 4 groups of 10 rats each.
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Conclusion & Impact:Conclusions: Honey and pollen were found to be effective in preventing postoperative intraabdominal adhesions, and these effects were thought to be a result of their antiinflammatory and antioxidant properties.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aims: We evaluated the effect of oral usage of honey and pollen, either separately or together, on postoperative intraabdominal adhesions. Methods: Forty rats were randomly separated into 4 groups of 10 rats each. Abrasion was performed on the cecum, and a patch of peritoneum located opposite to the cecal abrasion was completely dissected. Group 1 rats received no treatment; Group 2 rats received 4 g/kg/day honey; Group 3 rats received 4 g/kg/day pollen; and Group 4 rats received 4 g/kg/day honey and pollen mixed in equal amounts, in addition to the standard feeding for postoperative 21 days. All the rats were sacrificed on the 21st day. Following the adhesion scoring, tissue specimens of the peritoneum and bowel were subjected to histopathological investigation. The tissue and blood specimens were also taken for biochemical analysis to investigate the antioxidant capacity. Results: Adhesion scores were significantly different between the control and other groups. No dense adhesion was observed in the treatment groups. Tissue malondialdehyde levels were significantly different between the control and honey and honey+pollen groups. Superoxide dismutase and glutathione-peroxidase levels were significantly different between the control and other groups. Catalase levels were different between the control and honey groups. Plasma antioxidant levels were different between the control and other groups. The pathological scores for fibrosis and inflammation were significantly different between the control and other groups. Conclusions: Honey and pollen were found to be effective in preventing postoperative intraabdominal adhesions, and these effects were thought to be a result of their antiinflammatory and antioxidant properties.

Özet

Amaç: Bal ve polenin oral yolla ve tek tek ya da birlikte kullanımının postoperatif intraabdominal adezyonlar üzerine etkisi değerlendirilmiştir. Yöntem: Kırk adet rat, rastlantısal olarak her biri onar adet rat içeren dört gruba ayrıldı. Çekum üzerinde abrazyon oluşturuldu ve bu çekal abrazyon bölgesinin karşısındaki periton parçası eksize edildi. Birinci grup herhangi bir tedavi almadı. Postoperatif 21 gün boyunca; standart beslenmeye ek olarak ikinci gruba 4 g/kg/gün bal, üçüncü gruba 4 g/kg/gün polen ve dördüncü gruba 4 g/kg/gün eşit miktarda karıştırılmış bal ve polen verildi. Tüm ratlar 21. gün sakrifiye edildi. Adezyon skorlamasını takiben; histopatolojik değerlendirme için periton ve barsaktan doku parçaları, ayrıca antioksidan kapasitenin araştırılması amacıyla biyokimyasal analiz için doku ve kan örnekleri alındı. Bulgular: Adezyon skorları, kontrol grubu ile diğer gruplar arasında belirgin olarak farklıydı. Tedavi gruplarında hiçbir ratta yoğun adezyon gözlenmedi. Doku malondialdehit seviyeleri kontrol grubu ile bal ve bal+polen grubu arasında belirgin olarak farklıydı. Süperoksit dismutaz ve glutatyon-peroksidaz düzeyleri kontrol grubu ile diğer gruplar arasında belirgin olarak farklıydı. Katalaz düzeyleri ise kontrol ve bal grupları arasında farklıydı. Plazma antioksidan düzeyleri de kontrol grubu ile diğer gruplar arasında farklıydı. Fibrozis ve inflamasyon yönünden patolojik skorlar kontrol ile diğer gruplar arasında belirgin olarak farklıydı. Sonuç: Bal ve polenin intraabdominal adezyonları önlemede etkili olduğu ve bu etkilerinin bu maddelerin antioksidan ve antiinflamatuvar etkilerine bağlı olduğu sonucuna varıldı.

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Cite This Article

CELEPLİ, S., KISMET, K., KAPTANOĞLU, B., EREL, S., ÖZER, S., CELEPLİ, P., KAYGUSUZ, G., DEVRİM, E., GENÇAY, Ö., SORKUN, K., Durak, İ., AKKUŞ, M. A. (2011). Oral bal ve polenin postoperatif intraabdominal adezyonlar üzerine etkisi. Turkish Journal of Gastroenterology, Cilt: 22 - Sayı: 1, 65–72. https://ajindex.com/articles/410825

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