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Journals / Turkish Journal of Gastroenterology / 2014 / Cilt: 25 - Sayı: 6

A case of uneventful ABO-incompatible liver transplantation from a deceased donor managed with routine immunosuppressive treatment

GÖKHAN TÜMGÖR
Recep TUNCER
RIZA DİNÇER YILDIZDAŞ
ABDULLAH ÜLKÜ
ATILGAN TOLGA AKÇAM
Haluk DEMİRYÜREK
Pages
730–732
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This case of ILT from a cadaveric donor is significant because the 2.5-year-old recipient did not experience any complications after undergoing routine immunosuppressive treatment.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:ABO-incompatible liver transplantation (ILT) was formerly contraindicated because of the increased risk of antibody-mediated humoral graft rejection due to preformed anti-A/-B antibodies on recipient endothelial cells.
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Key Findings & Data:A 2.5-year-old girl with end-stage liver disease underwent cadaveric donation ILT because of acute liver failure and esophageal variceal bleeding before transplantation.
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Conclusion & Impact:This case of ILT from a cadaveric donor is significant because the 2.5-year-old recipient did not experience any complications after undergoing routine immunosuppressive treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

ABO-incompatible liver transplantation (ILT) was formerly contraindicated because of the increased risk of antibody-mediated humoral graft rejection due to preformed anti-A/-B antibodies on recipient endothelial cells. A 2.5-year-old girl with end-stage liver disease underwent cadaveric donation ILT because of acute liver failure and esophageal variceal bleeding before transplantation. The patient's blood type was A Rh (-) and the donor's blood type B Rh (+). The operation and postoperative course were uneventful. The immunosuppression consisted of steroids, and tacrolimus was initiated on the day of the surgery. The patient's hemoglobin level did not change, and direct Coombs test performed daily was consistently negative. Anti-B titer was observed at a maximum of 1/8. The patient was followed up during the first year. This case of ILT from a cadaveric donor is significant because the 2.5-year-old recipient did not experience any complications after undergoing routine immunosuppressive treatment.

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Cite This Article

TÜMGÖR, G., TUNCER, R., YILDIZDAŞ, R. D., ÜLKÜ, A., AKÇAM, A. T., DEMİRYÜREK, H. (2014). A case of uneventful ABO-incompatible liver transplantation from a deceased donor managed with routine immunosuppressive treatment. Turkish Journal of Gastroenterology, Cilt: 25 - Sayı: 6, 730–732. https://ajindex.com/articles/410764

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References (14)

  1. Nakamura Y, Hama K, Iwamoto H, et al. Long-Term RecurrenceFree Survival after Liver Transplantation from an ABO-Incompatible Living Donor for Treatment of Hepatocellular Carcinoma Exceeding Milano Criteria in a Patient with Hepatitis B Virus Cirrhosis: A Case Report. Transplant Proc 2012; 44: 565-9
  2. Matsuno N, Nakamura Y, Mejit A, et al. Long-term follow-up ABOincompatible adult living donor liver transplantation in cirrhotic patients. Clin Transplant 2007; 21: 638
  3. Egawa H, Oike F, Buhler L, et al. Impact of recipient age on outcome of ABO-incopatible living donor liver transplantation. Transplantation 2004; 77: 403-11
  4. Tanabe M, Kawachi S, Obara H, et al. Current progress in ABO-incompatible liver transplantation. Eur J Clin Invest 2010; 40: 943-9
  5. Soin AS, Raut V, Mohanka R, et al. The use of ABO-incompatible grafts in living donor liver transplantation-first report from India. Indian J Gastroenterol 2014; 33: 72-6
  6. Kawagishi N, Takeda I, Miyagi S, et al. Long-term outcome of ABOincompatible living-donor liver transplantation: a single-center experience. J Hepatibiliary Pancreat Surg 2009; 16: 468-72
  7. Toso C, Al-Qahtani M, Alsaif Fa, et al. ABO-incompatible liver transplantation for critically ill adult patients. Transpl Int 2007; 20: 675-81
  8. Pratschke J, Tullius Sg. Promising recent data on ABO incompatible liver transplantation: restrictions may apply. Transpl Int 2007; 20: 647-8
  9. Egawa H, Teramukai S, Haga H, Tanabe M, Fukushima M, Shimazu M. Present status of ABO-incompatible living donor liver transplantation in Japan. Hepatology 2008; 47:143-52
  10. Tanabe M, Shimazu M, Wakabayashi G, et al. Intraportal infusion therapy as a novel approach to adult ABO-incompatible liver transplantation. Transplantation 2002; 73:1959
  11. Oike F, Kamei H, Tanaka K. Novel approaches for ABO blood-type incompatible liver transplantation from living donor: Intraportal infusion therapy and hepatic arterial infusion therapy. Konnichi No Ishoku 2003; 16: 479
  12. Takahashi K. A new concept of accommodation in ABO incompatible kidney transplantation. Clin Transplant 2005; 19: 76
  13. Raut V, Mori A, Kaido T, et al. Splenectomy Does Not Offer Immunological Benefits in ABO-Incompatible Liver Transplantation With a Preoperative Rituximab. Transplantation 2012; 93: 99-105
  14. Gelas T, McKiernan PJ, Kelly DA, et al. ABO-incompatible pediatric liver transplantation in very small recipients: Birmingham's experience Pediatr Transplantation 2011: 15: 7