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Journals / Turkish Journal of Gastroenterology / 2017 / Cilt: 28 - Sayı: 5

Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease

Murat ÇAKIR
Ayşe Aksel İŞBİLEN
İlker EYÜPOĞLU
Elif SAĞ
ASIM ÖREM
Tuğba Mazlum ŞEN
NEŞE KAKLIKKAYA
Gülay KAYA
Pages
377–383
DOI
—
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Conclusion: Synbiotic supplementation in addition to lifestyle changes is effective in children with NAFLD.

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Objective & Hypothesis:Background/Aims: We aimed to analyze the efficiency of a novel treatment approach, long-term synbiotic supplementation, in addition to lifestyle changes in children with non-alcoholic fatty liver disease (NAFLD).Materials and Methods: The study included children with NAFLD (n=28) and a healthy control group (n=30).
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Key Findings & Data:Children with NAFLD were given 1 capsule/day of synbiotics.
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Conclusion & Impact:Conclusion: Synbiotic supplementation in addition to lifestyle changes is effective in children with NAFLD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Background/Aims: We aimed to analyze the efficiency of a novel treatment approach, long-term synbiotic supplementation, in addition to lifestyle changes in children with non-alcoholic fatty liver disease (NAFLD).Materials and Methods: The study included children with NAFLD (n=28) and a healthy control group (n=30). Children with NAFLD were given 1 capsule/day of synbiotics. Anthropometric parameters; biochemical analysis, including ethanol, tumor necrosis factor-? (TNF-?), total oxidant status (TOS) and anti-oxidant status (TAS), zonulin, and fecal calprotectin; and ultrasonographic examination were performed at baseline and 4 months later.Results: The grade of fatty liver was decreased (>=1 grade) in 19 of the 28 patients (67.8%) after synbiotic supplementation. Total cholesterol, low-density lipoprotein (LDL) levels, TNF-?, C-reactive protein (CRP), and ethanol were significantly decreased, and TAS levels were significantly increased at the end of treatment (p<0.05 for all). We found that the median decrease in CRP (-0.16 vs. -0.03 mg/dL, p=0.003) and LDL levels (-17 vs. -3 mg/dL, p=0.019) were higher in patients who responded to the supplementation. Conclusion: Synbiotic supplementation in addition to lifestyle changes is effective in children with NAFLD.

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Cite This Article

ÇAKIR, M., İŞBİLEN, A. A., EYÜPOĞLU, İ., SAĞ, E., ÖREM, A., ŞEN, T. M., KAKLIKKAYA, N., KAYA, G. (2017). Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease. Turkish Journal of Gastroenterology, Cilt: 28 - Sayı: 5, 377–383. https://ajindex.com/articles/410722

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