Gastrointestinal lenfomalarda Ki-67 ve BCL-2 ilişkisi

Key Findings & Data:The proliferation rate was determined as a proliferation index of ki-67 (MIB-1) positive nuclei and the cell death was estimated indirectly by using apoptosis regulating protein bcl-2.

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Conclusion & Impact:Results: The proliferation index (PI) of the high grade group was 40.5% where it was found to be 24.5% for low grade lymphomas (p=0.14).

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Tanı teknikleri · sindirim sistemi · Gastrointestinal neoplazmlar

Abstract

We investigated the relationship between the proliferation rate and the cell death of primary gastrointestinal lymphomas. The proliferation rate was determined as a proliferation index of ki-67 (MIB-1) positive nuclei and the cell death was estimated indirectly by using apoptosis regulating protein bcl-2. Methods: Proliferation marker ki-67 (MIB-1) and apoptosis regulating protein bcl-2 were studied by immunohistochemical method in 20 primary gastrointestinal lymphomas that were diagnosed between January 1990 and July 1999. There were 10 low grade and 10 high grade primary gastrointestinal lymphomas. Results: The proliferation index (PI) of the high grade group was 40.5% where it was found to be 24.5% for low grade lymphomas (p=0.14). Seven (70%) low grade and four (40%) high grade lymphomas were bcl-2 positive (p=0.37). Conclusion: No relationship was found between PI and bcl-2 positivity (p=0.31).

Özet

Çalışmamızda gastrointestinal lenfomalarda proliferasyon hızı ile hücre ölümü arasındaki ilişki araştırılmıştır. Proliferasyon hızı ki-67 (MIB-1) indeksi ile, hücre ölümü ise apoptozis regule eden protein bcl-2 ile dolaylı olarak saptanmıştır. Yöntem:Ocak 1990 ve Temmuz 1999 yılları arasında gastrointestinal lenfoma tanısı alan 20 olguda immunohistokimyasal yöntem ile proliferasyon belirteci ki-67 (MIB-1) ve apoptozis regüle eden protein bcl-2 çalışılmıştır. Bulgular:Olguların 10'u düşük malignite gösteren, 10'u yüksek dereceli malignite gösteren grupta değerlendirildi. Yüksek dereceli malignite gösterenlerde proliferasyon indeksi (PI) % 40.5, düşük dereceli malignite gösterenlerde ise %24.5 olarak saptandı (p=0.14). Düşük dereceli olguların 7'sinde (% 70) bcl-2 pozitifliği izlenirken aynı değer yüksek dereceli grupta 4 (% 40) olarak bulundu (p= 0.37). Sonuç:Çalışmamızda PI ile bcl-2 pozitivitesi arasında bir ilişki bulunamadı (p=0.31).

Keywords

Tanı teknikleri sindirim sistemi Gastrointestinal neoplazmlar İmmünohistokimya Lenfom Biyolojik belirteçler Proto-onkojen proteinler c-bcl-2 Diagnostic Techniques Digestive System Gastrointestinal Neoplasms Immunohistochemistry Lymphoma Biological Markers Proto-Oncogene Proteins c-bcl-2

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Cite This Article

PEŞDERELİ, H. E., GÜLKESEN, K. H., ERDOĞAN, G., GELEN, M. T., KARPUZOĞLU, G., SÜLEYMANLAR, İ., SARGIN, C. F. (2000). Gastrointestinal lenfomalarda Ki-67 ve BCL-2 ilişkisi. Turkish Journal of Gastroenterology, Cilt: 11 - Sayı: 4, 305–308. https://ajindex.com/articles/410513

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