AI Summary & Key Takeaways
AI InsightConclusion: It is concluded that cirrhosis is associated with delayed gastric emptying.
📌 3 Key Takeaways
Abstract
Background/aims: The aim of this study was to investigate whether gastroparesis occurs in cirrhotic patients with known portal gastropathy and, whether this may cause dyspeptic symptoms commonly seen in this patient population. Methods: The study included 20 cirrhotic patients with portal gastropathy (11 male, nine female, median age 48,6±18,5 years) and ten age/sex matched healthy control subjects. Symptoms of abdominal pain, discomfort, bloating, or heartburn were noted. Those with upper gastrointestinal malignancies, gallstones and gastroesophageal reflux were excluded following endoscopy and abdominal ultrasonography. Medications which may affect intestinal motility were suspended at least 24 hours prior to the study. A solid-phase scintigraphic gastric emptying study was performed and the gastric emptying half time was calculated. Results: There were no endoscopic signs of peptic ulceration or gastroesophageal reflux disease in either patients or controls. Mean gastric emptying half time was found to be delayed in cirrhotic patients compared, to that of controls (79.46±24.84 vs 55.06±17.69 min, respectively, p>0.05). Six of the cirrhotic patients were free of gastrointestinal symptoms while 14 had dysmotility like symptoms. Although the mean the gastric emptying half time measurements were longer in symptomatic patients, the two groups of cirrhotics with and without dyspepsia showed no significant difference in the gastric emptying half time (84±16.4 min vs 72±17.9 min, respectively, p>0.05). Conclusion: It is concluded that cirrhosis is associated with delayed gastric emptying.
Özet
Amaç: Bilinen siroz ve portal gastropati teşhisi olan hastalarımızda gastroparezi varlığını araştırmayı ve sonuçlarımızın bu hastalardaki dispeptik yakınmalara olan katkısını bulmayı amaçladık. Yöntem: Portal gastropatisi olan 20 sirotik hasta (11 erkek, 9 kadın, medyan yaş 48,6+18,5 yıl) ve 10 sağlıklı bireyde mide boşalma zamanı çalışıldı. Üst gastrointestinal malignasiler, safra taşları, gastroözofageal reflü hastalığı endoskopik ve ultrasonografik yöntemler ile ekarte edilmeye çalışıldı. Mide boşalması zamanı sintigrafik yöntem ile yapıldı ve tüm bireylerde mide boşalma zamanı hesaplandı. Yirmi hastanın 14'ünde dismotilite tipi dispeptik yakınmalar vardı. Altı hasta ise dispeptik yakınma tariflemiyordu. Bulgular: Üst endoskopide hiç bir hastada veya kontrol grubunda peptik ülserasyon veya gastroözofageal reflü hastalığı bulgusu yoktu. Mide boşalma zamanı ölçümleri sirotik hastalarda mide boşalmasının kontrollere göre anlamlı olarak geciktiğini göstermiştir (79.46+24.84 dk, 55.06+17.69 dk , p 0.05). Sonuç: Bu çalışmanın verilerine dayanarak, siroz hastalarında mide boşalmasının sağlıklı bireylere göre anlamlı derecede geciktiği ortaya konmuştur.