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Journals / Turkish Journal of Gastroenterology / 2002 / Cilt: 13 - Sayı: 2

Kronik gastrit ve duodenal ülserli vakalarda Helicobacter pylori yoğunluğu ve histopatolojik bulgular arasındaki ilişki

The relationship between Helicobacter pylori intensity and histopathological findings in cases with chronic gastritis and duodenal ulcer

Şahande ALAGÖZ
Cansel TÜRKAY
NACİYE ÖZLEM SAYGILI YÖNEM
Pages
98–102
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: As morphological characteristics are crucial for the early diagnosis and treatment of gastric malignities; histopathological confirmation of helicobacter intensity is important.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aims: Helicobacter pylori infection affects many people in developing countries.
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Key Findings & Data:Methods: Fifty patients (35 cases with gastritis and 15 with duodenal ulcer) were included in the study.
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Conclusion & Impact:Conclusion: As morphological characteristics are crucial for the early diagnosis and treatment of gastric malignities; histopathological confirmation of helicobacter intensity is important.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Helicobacter pylori · Gastrit · Mide neoplazmları

Abstract

Background/aims: Helicobacter pylori infection affects many people in developing countries. The inflammation it induces can cause malignant gastric lymphoma and also gastric carci-noma, depending on the intensity of inflammatory reaction, specific properties related to the strain and the host response. Methods: Fifty patients (35 cases with gastritis and 15 with duodenal ulcer) were included in the study. Hematoxylin-eosin paraffin sections were prepared from their endoscopic biopsies and Helicobacter pylori presence, activity of the infection, lymphoplasrnacytoid cell infiltration and the degree of atrophy were determined semiquantitatively. Toludin O stain was applied to determine Helicobacter pylori intensity. Results: We found a statistically significant positive correlation of Helicobacter pylori intensity and activity of infection, lymphoplasmacytoid cell infiltration and atrophy in the 35 cases with gastritis and the relationship between Helicobacter pylori intensity and inflammatory activity was statistically significant in the 15 cases with duodenal ulcer. Conclusion: As morphological characteristics are crucial for the early diagnosis and treatment of gastric malignities; histopathological confirmation of helicobacter intensity is important.

Özet

Amaç: Helicobacter pylori gelişmekte olan ülkelerdeki pek çok bireyi etkilemektedir. Helicobacter pylori'nin indüklediği inflamasyon; inflamatuar reaksiyonun şiddeti, suşa ait spesifik özellikler ve konak cevabına bağlı olarak malign gastrik lenfoma ve gastrik karsinomaya neden olabilir. Yöntem: Çalışmamıza 50 vaka (35 gastritli, 15 duodenal ulkuslu) dahil edildi. Bu hastaların endoskopik biyopsilerinden hematoksilen-eozin kesitler elde edildi. Semikantitatif olarak Helicobacter pylori varlığı, infeksiyonun aktivasyonu, lenfo-plazmositer hücre infiltrasyonu ve atrofi derecesi değerlendirildi. Helicobacter pylori şiddetini belirlemek için toluidin-O boyası kullanıldı. Bulgular: Gastritli 35 vakada Helicobacter pylori'nin şiddeti ile enfeksiyonun aktivasyonu, lenfoplazmositer hücre infiltrasyonu ve atrofi arasında istatistiksel açıdan anlamlı pozitif bir ilişki saptanırken, duodenal ulcuslu 15 vakada iltihabı aktivasyon ile Helicobacter pylori yoğunluğu arasındaki ilişki istatistiksel olarak anlamlı idi. Sonuç: Gastrik kanserlerin erken tanı ve tedavisinde morfolojik özellikler önemli olduğundan; Helicobacter pylori yoğunluğunun histopatolojik olarak gösterilmesi gereklidir.

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Cite This Article

ALAGÖZ, Ş., TÜRKAY, C., YÖNEM, N. Ö. S. (2002). Kronik gastrit ve duodenal ülserli vakalarda Helicobacter pylori yoğunluğu ve histopatolojik bulgular arasındaki ilişki. Turkish Journal of Gastroenterology, Cilt: 13 - Sayı: 2, 98–102. https://ajindex.com/articles/410440

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