Journals / Turkish Journal of Gastroenterology / 2003 / Cilt: 14 - Sayı: 1

Kısa segment Barrett özofagusun midedeki intestinal metaplazi ile ilişkisi

The association of short segment Barrett's esophagus with intestinal metaplasia in stomach

Pages
33–38
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The link between intestinal metaplasia in the stomach and these metaplastic changes in the tubular esophagus requires evalation in larger and more comprehensive studies.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aims: The aims of this study were to investigate the presence of short segment Barrett's esophagus in people found to have tongue-like columnar mucosal protrusions in the distal esophagus and to determine the relationship between short segment Barrert's esophagus and Helicobacter pylori, gastritis and intestinal metaplasia observed in other parts of the stomach.
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Key Findings & Data:Methods: The study included 50 patients (32 male, 18 female).
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Conclusion & Impact:The link between intestinal metaplasia in the stomach and these metaplastic changes in the tubular esophagus requires evalation in larger and more comprehensive studies.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Barrett özefagus · Gastrit · Helicobacter pylori

Abstract

Background/aims: The aims of this study were to investigate the presence of short segment Barrett's esophagus in people found to have tongue-like columnar mucosal protrusions in the distal esophagus and to determine the relationship between short segment Barrert's esophagus and Helicobacter pylori, gastritis and intestinal metaplasia observed in other parts of the stomach. Methods: The study included 50 patients (32 male, 18 female). Two biopsy specimens were taken from the antrum, at least 2 cm away from the pylorus, from the incisura angularis, corpus and cardia and four biopsy specimens were taken from tongue-like columnar protrusions (<3 cm long) above the gastroesophageal junction. Tissue samples were stained with hematoxylineeosine, HID-Alcian blue pH 2.5 and modified Giemsa. Results: Of the 50 subjects who were found to have tongue-like columnar protrusions above the gastroesophageal junction, short segment Barrett's esophagus was detected in nine (18%). Whereas all short segment Barretti's esophagus cases were associated with chronic gastritis, Helicobacter pylori was found to be positive in five (55.5 %) of them and there was intestinal metaplasia in other parts of the stomach (antrum in two patients, incisura angularis in three, antrum and cardia in one) in six (66.6 %) cases. In 41 patients without short segment Barrett's esophagus 33 (80%) had chronic gastritis, 27 (66%) had Helicobacter pylori infection and eight had intestinal metaplasia in different locations (there in antrum, four in incisura angularis, one in the antrum and cardia) of the stomach. Conclusions: An association between short segment Barrett's esophagus and intestinal metaplasia was found in different parts of the stomach. The link between intestinal metaplasia in the stomach and these metaplastic changes in the tubular esophagus requires evalation in larger and more comprehensive studies.

Özet

Amaç: Distal özofagusta dil şeklinde kolumnar mukozal uzantıları olan hastalarda kısa segment Barrett özofagus (KSBÖ) varlığını araştırmak ve kısa segment Barrett özofagus ile H.pylori, kronik gastrit ve midenin farklı lokahzasyonlarında saptanan intestinal metaplazi arasındaki ilişkiyi belirlemektir. Yöntem: Distal özofagusta dil seklinde kolumnar mukozal uzantıları (< 3cm uzunlukta) saptanan 50 hasta (32 erkek, 18 kadın) çalışmaya alındı. Biyopsiler sırasıyla antrum, incisura angularis, korpus büyük kurvatur ve kardiadan iki adet, gastroözofageal bileşkenin üzerindeki mukozal uzantılardan dört adet olmak üzere alındı. Doku örnekleri hematoxyline - eosine, HID-Alcian blue pH 2.5 ve modified Giemsa ile bayandı. Bulgular: gastroözofageal'nin üstünde dil şeklinde kolumnar mukozal uzantıları olan 50 hastanın dokuzunda (%18) kısa segment Batters özafagus tespit edildi. Kısa segment Barrett özofagus saptanan olguların tümünde kronik gastrit, beşinde (%55) H.pylori pozitifliği, altısında (%66) midenin farklı lokalizasyonlarında (antrum 2, incisura angularis 3, antrum ve kardia 1) intestinal metaplazi bulundu. Oysa kısa segment Barrett özofagus saptanmayan 41 olgunun 33'ünde (%80) kronik gastrit, 27'sinde (%66) H.pylori, sekizinde (%19.6) midenin farklı lokalizasyonlarında (antrum 3, incisura angularis 4, antrum ve kardia 1) intestinal metaplazi tespit edildi. Sonuç: Kısa segment Barrett özofagus, midenin farklı lokalizasyonlarında tespit edilen intestinal metaplazi ile birliktelik gösteriyordu. Şöyle ki kısa segment Barrett özofagus'lu olguların 2'sinde antrum, 3'ünde insisura angularis, birinde antrum ve kardiyada metaplazi tespit edilirken, kısa segment Barrett özofagus saptanmayan olguların 3'ünde antrum, 4'ünde insisura angularis ve birinde korpusta metaplazi saptandı. Tubuler özofagus içinde saptanan bu metaplazik değişiklikler ile midedeki intestinal metablaplazinin birlikteliğine dair daha kapsamlı çalışmaların yapılması yararlı olacaktır.

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Cite This Article

TUNCER, İ., UĞRAŞ, S., UYGAN, İ., TÜRKDOĞAN, K., KÖSEM, M. (2003). Kısa segment Barrett özofagusun midedeki intestinal metaplazi ile ilişkisi. Turkish Journal of Gastroenterology, Cilt: 14 - Sayı: 1, 33–38. https://ajindex.com/articles/410407

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