Journals / Turkish Journal of Gastroenterology / 2013 / Cilt: 24 - Sayı: 4

The prevalence of celiac disease in children with iron-deficiency anemia

Demir eksikliği anemisi olan çocuklarda çölyak hastalığı

Pages
334–338
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The mean hemoglobin level was significantly lower in iron-deficiency anemia patients with celiac disease when compared to those without celiac disease (7,8±2,6 vs. 11,3±0,9 g/dL, p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aims: Celiac disease is an immune-mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals.
📊
Key Findings & Data:Ma- terials and Methods: A total of 61 patients aged 2-16 years who presented with iron-deficiency anemia were included in this study.
💡
Conclusion & Impact:The mean hemoglobin level was significantly lower in iron-deficiency anemia patients with celiac disease when compared to those without celiac disease (7,8±2,6 vs. 11,3±0,9 g/dL, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aims: Celiac disease is an immune-mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals. Iron-deficiency anemia is the most commonly encountered anemia in humans. Iron-deficiency anemia also is a common extraintestinal manifestation of celiac disease. To determine the celiac disease prevalence in children with iron-defi- ciency anemia and to compare the hematologic parameters in iron-deficiency anemia patients with and without celiac disease. Ma- terials and Methods: A total of 61 patients aged 2-16 years who presented with iron-deficiency anemia were included in this study. Hemoglobin, red cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentrati- on, red cell distribution width), serum iron, and serum ferritin were determined. Venous blood samples for anti-tissue transgluta- minase antibody immunoglobuline A were obtained from these patients. Upper gastrointestinal endoscopy was recommended to pa- tients who had positive serology. Results: Of 61 patients with iron-deficiency anemia, 13 (21,3%) had positive serology for celiac disease. The small intestine biopsy of all patients with positive serology showed villous atrophy (Marsh 3). The mean hemoglobin level was significantly lower in iron-deficiency anemia patients with celiac disease when compared to those without celiac disease (7,8±2,6 vs. 11,3±0,9 g/dL, p

Özet

Giriş ve Amaç: Çölyak hastalığı genetik olarak yatkın kişilerde glutene karşı kalıcı hassasiyetle ortaya çıkan immün aracılı bir enteropatidir. Demir eksikliği anemisi insanlarda en çok görülen anemidir. Demir eksikliği anemisi aynı zamanda çölyak hasta- lığının en yaygın görülen ekstraintestinal bulgularından biridir. Bu çalışmada amacımız demir eksikliği anemisi olan çocuklarda çölyak hastalığı prevalansını belirlemek ve bu hastalardaki hematolojik parametreleri çölyak hastalığı olmayan demir eksikliği anemisi olan hastalarınkiyle karşılaştırmaktı. Gereç ve Yöntem: 2-16 yaşları arası demir eksikliği anemisi olan 61 hasta çalış- maya alındı. Hastaların hemoglobin, eritrosit indeksleri (ortalama eritrosit hacmi, ortalama eritrosit hemoglobini, ortalama erit- rosit hemoglobin konsantrasyonu, eritrosit dağılım genişliği), serum demir ve ferritin düzeyleri değerlendirildi. Hastalardan anti- transglutaminaz immunglobulin A çalışmak için venöz kan örnekleri alındı. Çölyak hastalığı serolojisi pozitif olan hastalara üst gastrointestinal sistem endoskopisi önerildi. Bulgular: Demir eksikliği anemili 61 hastanın 13'ünde (%21,3) çölyak hastalığı sero- lojisi pozitifti. Bu hastaların ince barsak biyopsisi villöz atrofi (Marsh 3) ile uyumluydu. Çölyak hastalarının ortalama hemoglo- bin seviyeleri çölyak hastalığı olmayan demir eksikliği anemili hastalarınkinden anlamlı derecede düşüktü (7,8±2,6 vs 11,3±0,9 g/dl) (p

🔖

Cite This Article

ERTEKİN, V., TOSUN, M. S., KÜÇÜK, N. (2013). The prevalence of celiac disease in children with iron-deficiency anemia. Turkish Journal of Gastroenterology, Cilt: 24 - Sayı: 4, 334–338. https://ajindex.com/articles/410285

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005; 40:1-19
  2. Zamani F, Mohamadnejad M, Shakeri R, et al. Gluten sensitive enteropathy in patients with iron deficiency anemia of unknown origin. World J Gastroenterol 2008; 14:7381-5
  3. Kalayci AG, Kanber Y, Birinci A, et al. The prevalence of coeliac disease as detected by screening in children with iron deficiency anaemia. Acta Paeditrica 2005; 94:678-81
  4. Baccini F, Spiriti MA, Vannella L, et al. Unawareness of gastrointestinal symptomatology in adult coeliac patients with unexplained iron-deficiency anaemia presentation. Aliment Pharmacol Ther 2006; 23:915-21
  5. Rodrigo L. Celiac diseae. World J Gastroenterol 2006; 12: 6585-93
  6. Ertekin V, Selimoglu MA, Kardas F, Aktafl E. Prevalence of celiac disease in Turkish children. J Clin Gastroenterol 2005; 39:689-91
  7. Corazza GR, Valentini RA, Andreani ML, et al. Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia. Scand J Gastroenterol 1995; 30:153-6
  8. Ransford RAJ, Hayes M, Palmer M, Hall MJ. A controlled, prospective screening study of celiac disease presenting as iron deficiency anemia. J Clin Gastroenterol 2002; 35:228-33
  9. Halfdanarson TR, Litzow MR, Murray JA. Hematologic manifestations of celiac disease. Blood 2007; 109:412-21
  10. Mody RJ, Brown PI, Wechsler DS. Refractory iron deficiency anemia as the primary clinical manifestation of celiac disease. J Pediatr Hematol Oncol 2003; 25:169-72
  11. Grisolano SW, Oxentenko AS, Murray JA, et al. The usefulness of routine small bowel biopsies in evaluation of iron deficiency anemia. J Clin Gastroenterol 2004; 38:756-60
  12. Kapur G, Patwari AK, Narayan S, Anand VK. Iron supplementation in children with celiac disease. Indian J Pediatr 2003; 70:955-8
  13. Rockey DC, Cello JP. Evaluation of the gastrointestinal tract in patients with iron-deficiency anemia. N Engl J Med 1993; 329:1691-5
  14. Carroccio A, Iannitto E, Cavataio F, et al. Sideropenic anemia and celiac disease: one study, two points of view. Dig Dis Sci 1998; 43:673-8
  15. Unsworth DJ, Lock RJ, Harvey RF. Improving the diagnosis of coeliac disease in anaemic womwn. Br J Haematol 2000; 111:898-901
  16. Lanzkowsky P. Manual of Pediatric Hematology and Oncology. San Diego, PA: Academic Pres; 2000
  17. Marsh MN. Gluten,