This method should be recommended when gluten-related disorders are suspected in order to reduce the inappropriate diagnosis of NCGS.
📌 3 Key Takeaways
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Objective & Hypothesis:We report three patients presenting with gluten-related signs and symptoms.
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Key Findings & Data:Since villous height/crypt depth ratio, intraepithelial lymphocyte count, and serum antibody tests were not diagnostic for celiac disease (CD), a diagnosis of non-celiac gluten sensitivity (NCGS) was suggested.
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Conclusion & Impact:This method should be recommended when gluten-related disorders are suspected in order to reduce the inappropriate diagnosis of NCGS.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
We report three patients presenting with gluten-related signs and symptoms. Since villous height/crypt depth ratio, intraepithelial lymphocyte count, and serum antibody tests were not diagnostic for celiac disease (CD), a diagnosis of non-celiac gluten sensitivity (NCGS) was suggested. On the other hand, antibodies suggestive for CD surprisingly showed positive results in the duodenal biopsy organ culture of all three cases. The reported cases suggest the precious potential role that organ culture systems may play in differentiating CD from NCGS. This method should be recommended when gluten-related disorders are suspected in order to reduce the inappropriate diagnosis of NCGS.
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Cite This Article
BORGHİNİ, R., DONATO, G., TOLA, M. D., ISONNE, C., PİCARELLİ, A. (2014). Mutatis mutandis: Are we diagnosing too many people with non-celiac gluten sensitivity? Multiple case report. Turkish Journal of Gastroenterology, Cilt: 25 - Sayı: 3, 319–322. https://ajindex.com/articles/410272
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