Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats

Key Findings & Data:We investigated the effects of methylprednisolone on intestinal oxidative damage and bacterial translocation in thioacetamideinduced liver failure in rats.Materials and Methods: Group 1 (n=8) was the control group.

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Conclusion & Impact:In group 4 (n=8), the methylprednisolone group, the rats.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Özet

Background/Aims: Steroids have been shown to prevent intestinal oxidative stress. We investigated the effects of methylprednisolone on intestinal oxidative damage and bacterial translocation in thioacetamideinduced liver failure in rats.Materials and Methods: Group 1 (n=8) was the control group. In group 2 (n=8), the thioacetamide group, rats received 300 mg/kg intraperitoneal thioacetamide daily for 2 days. In group 3 (n=8), the thioacetamide+methylprednisolone group, treatment with methylprednisolone (30 mg/kg intraperitoneal) was commenced 48 h before the first dose of thioacetamide. In group 4 (n=8), the methylprednisolone group, the rats.

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Cite This Article

HARPUTLUOĞLU, M. M. M., TEMEL, İ., DEMİREL, U., SEÇKİN, Y., ALADAĞ, M., OTLU, B., KARADAĞ, N., ÖZYALIN, F., AYDOĞAN, N., SELÇUK, E. B. (2017). Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats. Turkish Journal of Gastroenterology, Cilt: 28 - Sayı: 5, 394–400. https://ajindex.com/articles/410180

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