There were no differences in theIMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.
📌 3 Key Takeaways
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Objective & Hypothesis:Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin(IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP).Materials and Methods: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) wereincluded in this study.
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Key Findings & Data:Serum thiols/SS and IMA concentrations were measured and compared between the two groups.Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group(224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively).
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Conclusion & Impact:There were no differences in theIMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin(IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP).Materials and Methods: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) wereincluded in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups.Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group(224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in theIMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.
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Cite This Article
UYANIKOĞLU, A., SABUNCU, T., YILDIZ, R., CİNDOĞLU, Ç., KİRMİT, A., EREL, Ö. (2019). Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turkish Journal of Gastroenterology, Cilt: 30 - Sayı: 10, 899–902. https://ajindex.com/articles/410050
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