Journals / Turkish Journal of Gastroenterology / 2006 / Cilt: 17 - Sayı: 2

Lokalize gastrik amiloidoz: Olgu sunumu

Localized gastric amyloidosis: A case report

Pages
116–119
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The clinical and pathological features of this rare condition and association with megaloblastic anemia are discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Local deposition of amyloid without systemic involvement is rather uncommon and has been found in many organs.
📊
Key Findings & Data:A 67-year- old man was admitted to our hospital presenting with weight loss, fatigue and poor appetite.
💡
Conclusion & Impact:The clinical and pathological features of this rare condition and association with megaloblastic anemia are discussed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Erkek · Yaşlı · Anemi

Abstract

Local deposition of amyloid without systemic involvement is rather uncommon and has been found in many organs. A 67-year- old man was admitted to our hospital presenting with weight loss, fatigue and poor appetite. Blood work and bone marrow examination revealed megaloblastic anemia. Upper gastrointestinal endoscopy reveeled e purple polypoid wass lesion of 5mm eliameter in the paracardiac region. Histopathologic examination of the gastric biopsy showed the deposition of amyloid materials in the mucosa. The patient had no evidence suggesting systemic amyloidosis. We report a rare case of localized amyloidosis of the stomach. The clinical and pathological features of this rare condition and association with megaloblastic anemia are discussed.

Özet

Sistemik tutulum olmaksızın lokal amiloid depolanması, nispeten nadirdir ve birçok organda görülür. 67 yaşında erkek hasta kilo kaybı, halsizlik ve iştahsızlık ile hastanemize başvurdu. Kan ve kemik iliği incelemeleri megaloblastik anemiyi ortaya çıkardı. Endoskopide parakardiak bölgede 5mm çapında pembe polipoid lezyon görüldü. Vakanın mide biyopsisinin histopatolojik incelemesinde mukozada amiloid birikimi gözlendi. Hastada sistemik amiloidozu düşündüren bulgular izlenmedi. Nadir görülen bir lokalize gastrik amiloidoz olgusunu rapor ettik. Bu nadir durumun klinik, patolojik özellikleri ve megaloblastik anemi ile ilişkisi tartışıldı.

🔖

Cite This Article

DENİZ, K., SARI, İ., TORUN, E., PATIROĞLU, T. E. (2006). Lokalize gastrik amiloidoz: Olgu sunumu. Turkish Journal of Gastroenterology, Cilt: 17 - Sayı: 2, 116–119. https://ajindex.com/articles/410012

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses: current approaches to diagnosis and treatment. N Engl J Med 1997; 337: 898–912
  2. Bjornsson S, Johannsson JH, Sigurjonsson F. Localized primary amyloidosis of the stomach presenting with gastric hemorrhage. Acta Med Scand 1987; 221: 115-6
  3. Ikeda K, Murayama H. A case of amyloid tumor of the stomach. Endoscopy 1978; 10: 54-8
  4. Wu D, Lou JY, Chen J, et al. A case report of localized gastric amyloidosis. World J Gastroenterol 2003; 9: 2632-4
  5. Gilat T, Revach M, Sohar E. Deposition of amyloid in the gastrointestinal tract. Gut 1969; 10: 98-104
  6. Yamada M, Hatekeyama S, Tsukagoshi H. Gastrointestinal amyloid deposition in AL (primary or myeloma-associated) and AA (secondary) amyloidosis: Diagnostic value of gastric biopsy. Hum Pathol 1985; 16: 1206-11
  7. Diseases of immunity. In: Cotran RS, Kumar V, Collins T, eds. Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: Saunders, 1999; 251–6
  8. Aoyagi K, Koufuji K, Yano S, et al. Early gastric carcinoma associated with amyloidosis: a case report. Kurume Med J 2002; 49: 153-6
  9. Overstreet K, Barone RM, Robin SH. Secondary amyloidosis and gastrointestinal stromal tumors: A case report and discussion of pathogenesis. Arch Pathol Lab Med 2003; 127: 470-3
  10. Caulet S, Robert I, Bardaxoglou E, et al. Malignant lymphoma of mucosa associated lymphoid tissue: A new etiology of amyloidosis. Pathol Res Pract 1995; 191: 1203-7
  11. Toh BH, van Driel IR, Gleeson PA. Pernicious anemia. N Engl J Med 1997; 337: 1441-8
  12. Tan SY, Pepys MB. Amyloidosis. Histopathology 1994; 25: 403-14
  13. Taylor KB. Immune aspects of pernicious anaemia and atrophic gastritis. Clin Haematol 1976; 5: 497-519.