Journals / Turkish Journal of Gastroenterology / 2007 / Cilt: 18 - Sayı: 4

Sağlıklı gönüllülerde oral etanolün gastrik miyoelektrik aktivite üzerine akut etkisi

The acute effect of oral ethanol intake on gastric myoelectrical activity in healthy volunteers

Pages
221–224
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Though reasonable blood alcohol level was achieved and six volunteers experienced upper gastrointestinal system complaints, ethanol had no effect on gastric myoelectrical activity.

📌 3 Key Takeaways

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Objective & Hypothesis:The acute effect of ethanol intake on the upper gastrointestinal system is not clearly known.
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Key Findings & Data:Results: On the days of ethanol intake, blood alcohol level reached above 80 mg/dl in 10 volunteers.
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Conclusion & Impact:Conclusions: Though reasonable blood alcohol level was achieved and six volunteers experienced upper gastrointestinal system complaints, ethanol had no effect on gastric myoelectrical activity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Mide · Referans değerleri · Etanol

Abstract

The acute effect of ethanol intake on the upper gastrointestinal system is not clearly known. Animal studies have shown that ethanol inhibited the antral muscle fiber contractions and slow wave activity. Background/aims: To show the acute effect of oral ethanol intake on gastric myoelectrical activity in healthy volunteers. Methods: Fourteen healthy male volunteers were included in the study. They were given control solution with test meal and ethanol with test meal on two different days. Electrogastrography recordings were obtained in pre-/postprandial periods. Results: On the days of ethanol intake, blood alcohol level reached above 80 mg/dl in 10 volunteers. Ethanol intake did not show any significant effect on any of the electrogastrography parameters. Conclusions: Though reasonable blood alcohol level was achieved and six volunteers experienced upper gastrointestinal system complaints, ethanol had no effect on gastric myoelectrical activity.

Özet

Etanolün üst gastrointestinal sistem üzerindeki akut etkisi tam olarak bilinmemektedir. Hayvan çalışmalarında, etanolün antral kas kontraksiyonlarını ve yavaş dalga aktivitesini inhibe ettiğ i gösterilmiştir. Amaç: Sağlıklı gönüllülerde, oral etanolün gastrik miyoelektrik aktivite üzerine akut etkisini göstermektir. Metod: On dört sağlıklı erkek gönüllü çalışmaya alınmıştır. Gönüllülere, bir gün, test yemeği ve kontrol solüsyonu, başka bir gün, test yemeği ve etanol verilmiş, pre ve postprandiyal dönemde elektrogastrografi kaydı alınmıştır. Sonuç: Etanol verilen günlerde, 10 gönüllüde, kan alkol düzeyi 80 mg/dl üzerine çıkmıştır. Etanol alımının elektrogastrografi parametreleri üzerine anlamlı etkisi gözlenmemiştir. Yorum: Yeterli kan alkol düzeyine erişilmiş olmasına ve altı gönüllüde üst gastrointestinal sistem yan etkileri ortaya çıkmasına rağmen, etanolün gastrik miyoelektrik aktivite etkilemediği görülmüştür.

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Cite This Article

KOBAK, Ç. A., BOR, S. (2007). Sağlıklı gönüllülerde oral etanolün gastrik miyoelektrik aktivite üzerine akut etkisi. Turkish Journal of Gastroenterology, Cilt: 18 - Sayı: 4, 221–224. https://ajindex.com/articles/409923

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References (17)

  1. Barboriak J, Meade RC. Effects of alcohol on gastric emptying in man. Am J Clin Nutr 1963; 23(9): 1151-3
  2. Brewster AC, Lankford HG. Ethanol and alimentary lipemia. Am J Clin Nutr 1966; 19 (4): 255-9
  3. Crean GP, Card WI, Beattie AD, et al. Ulcer-like dyspepsia. Scand J Gastroenterol Suppl. 1982; 79: 9-15
  4. Pihkanen TA. Neurological and physiological studies on distilled and brewed beverages. Ann Med Exp Biol Fenn 1957; 35 (Suppl): 9
  5. Mushambi MC, Bailey SM, Trotter TN. Effect of alcohol on gastric emptying in volunteers. Br J Anaesth 1993; 71: 674- 6
  6. Knight LC, Maurer AH, Wikander R. Effect of ethyl alcohol on motor function in canine stomach. Am J Physiol 1992; 262 (2 pt 1): G 223-30
  7. Sanders KM, Bauer AJ. Ethyl alcohol interferes with excitation- contraction mechanisms of canine antral muscle. Am J Physiol 1982; 242(3): G222-30
  8. Reed JB, Bauer AJ, Sanders KM. Electrical basis for the effects of ethyl alcohol on canine corpus muscles. Eur J Pharmacol 1985; 119 (1-2): 31-7
  9. Berry RG, Sanders KM. Mechanical effects of ethyl alcohol on muscles of the proximal stomach. Proc West Pharmacol Soc 1984; 27: 115-7
  10. Sanders KM, Berry RG. Effects of ethyl alcohol on phasic and tonic contractions of the proximal stomach. J Pharmacol Exp Ther 1985; 235 (3): 858-63
  11. Chen JDZ, McCallum RW. Clinical applications of electrogastrography. Am J Gastroenterol 1993; 88: 1324-36
  12. Stern RM, Koch KL, Stewart WR. Electrogastrography: current issues in validation and methodology. Psychophysiology 1987; 24: 55-64
  13. Shimada Y, Watanabe M, Shibahara N, et al. Electrogastrographic power ratio in humans is not related to changes in antrum-skin distance but to antral motility. J Gastroenterol 1998; 33(3): 310-7
  14. Crankshaw DL, Briggs JE, Olszewski PK. Effects of intracerebroventricular ethanol on ingestive behavior and induction of c-Fos immunoreactivity in selected brain regions. Physiol Behav 2003; 79: 113-20
  15. Brzozowski T, Konturek PC, Konturek SJ. Central leptin and cholecystokinin in gastroprotection against ethanol-induced damage. Digestion 2000; 62: 126-42
  16. Izbeki F, Wittmann T, Jancso G, et al. Inhibition of gastric emptying and small intestinal transit by ethanol is mediated by capsaicin-sensitive afferent neurons. Naumyn Schmiedebergs Arch Pharmacol 2002; 365 (1): 17-21
  17. Jedrzejewska A, Staff-Zielinska E. Neuropathology of intramural autonomic innervation of mice stomach in chronic ethanol intoxication. Zentralbl Allg Pathol