AI Summary & Key Takeaways
AI InsightThis finding might have impact on the clinical consequences for the treatment strategies in dyspepsia.
📌 3 Key Takeaways
Abstract
Background/aims: We aimed to determine the distribution of cytochrome P450 2C19 (CYP2C19) genotype frequencies in Turkish patients with dyspepsia. Methods: CYP2C19 genotype was determined in 100 Turkish patients with dyspepsia. DNA of the patients was isolated from whole blood and genotypes were detected by specific probes in real-time polymerase chain reaction (PCR). Results: The frequencies of heterozygous CYP2C19*2 and CYP2C19*3 genotypes were 13% and 1% in dyspeptic patients, respectively. Homozygous mutant CYP2C19*2 was detected at a rate of only 1% in the study population, and homozygous mutant genotype of CYP2C19*3 was not found. The frequencies of homozygous CYP2C19*2 and CYP2C19*3 genotypes were 86% and 99% in dyspeptic Turkish patients, respectively. Conclusions: This is the first study investigating CYP2C19 polymorphism in dyspeptic Turkish patients. Our investigation revealed that the most common CYP2C19 genotype was wild type CYP2C19 in dyspeptic Turkish patients. Dyspeptic Turkish patients are extensive metabolizers for proton pump inhibitors. This finding might have impact on the clinical consequences for the treatment strategies in dyspepsia.
Özet
Amaç: Dispeptik yakınmaları olan Türk hastalarda cytocrom P450 2C19 enziminin genotipik dağılımını belirlemek. Yöntem: Dispeptik yakınmaları olan 100 Türk hastada CYP2C19 genotipi belirlendi. Hastaların DNA'lı kandan ayrıldı ve genotipler real-time PCR ile spesifik problarla saptandı. Bulgular: Dispeptik hastalarda heterozigot CYP2C19*2 ve CYP2C19*3 genotipi sırasıyla %13 ve %1 saptandı. Çalışma hastalarının sadece birinde (%1) homozigot mutant CYP2C19*2 saptandı. Dispeptik hastalarda homozigot mutant CYP2C19*3 bulunmadı. Dispeptik Türk hastalarda homozigot CYP2C19*2 ve CYP2C19*3 genotipleri sırasıyla %86 ve %99 olarak bulundu. Sonuç: Bu araştırma dispeptik Türk hastalarda CYP2C19 polimorfizminin araştırıldığı ilk çalışmadır. Çalışmamız dispeptik Türk hastalarda en sık görülen CYP2C19 genotiplerinin homozigot CYP2C19*2 ve CYP2C19*3 olduğunu göstermektedir. Dispeptik Türk hastalar Proton Pompa İnhibitörleri için hızlı metabolize edicidirler. Bu bulgular dispepsi tedavisinin klinik sonuçlarında etkili olabilir.